3-(2'-Cyano-biphenyl-4-ylmethyl)-2-ethylamino-3H-benzoimidazole-4-carboxylic acid methyl ester

Base Information

Chemical Name:3-(2'-Cyano-biphenyl-4-ylmethyl)-2-ethylamino-3H-benzoimidazole-4-carboxylic acid methyl ester
CAS No.:139481-56-4
Molecular Formula:C₂₅H₂₂N₄O₂
Molecular Weight:410.475
Hs Code.:

Synonyms:3-(2'-Cyano-biphenyl-4-ylmethyl)-2-ethylamino-3H-benzoimidazole-4-carboxylic acid methyl ester

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Chemical Property of 3-(2'-Cyano-biphenyl-4-ylmethyl)-2-ethylamino-3H-benzoimidazole-4-carboxylic acid methyl ester

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Technology Process of 3-(2'-Cyano-biphenyl-4-ylmethyl)-2-ethylamino-3H-benzoimidazole-4-carboxylic acid methyl ester

There total 9 articles about 3-(2'-Cyano-biphenyl-4-ylmethyl)-2-ethylamino-3H-benzoimidazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21606-04-2
methyl 2-carboxy-3-nitrobenzoate

: 139481-56-4
3-(2'-Cyano-biphenyl-4-ylmethyl)-2-ethylamino-3H-benzoimidazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: SOCl₂, DMF / toluene / 0.5 h / Heating

2: NaN₃ / acetone; H₂O / 1 h

3: 1.5 h / Heating

4: 85 percent / K₂CO₃ / acetonitrile / 4 h / Heating

5: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature

6: 1.) FeCl₃*6H₂O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h

7: 96 percent / ethanol / 17 h / 50 °C

8: 1.) methyl iodide, 2.) HCl / 1.) EtOH, reflux, 24 h, 2.) EtOH, H₂O

With hydrogenchloride; thionyl chloride; sodium azide; potassium carbonate; pyrographite; hydrazine hydrate; N,N-dimethyl-formamide; methyl iodide; In ethanol; water; ethyl acetate; acetone; toluene; acetonitrile;
DOI:10.1021/jm00067a016

Reference yield:

: 73833-13-3
acid chloride of 1-methylhydrogen-3-nitrophthalate

: 139481-56-4
3-(2'-Cyano-biphenyl-4-ylmethyl)-2-ethylamino-3H-benzoimidazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: NaN₃ / acetone; H₂O / 1 h

2: 1.5 h / Heating

3: 85 percent / K₂CO₃ / acetonitrile / 4 h / Heating

4: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature

5: 1.) FeCl₃*6H₂O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h

6: 96 percent / ethanol / 17 h / 50 °C

7: 1.) methyl iodide, 2.) HCl / 1.) EtOH, reflux, 24 h, 2.) EtOH, H₂O

With hydrogenchloride; sodium azide; potassium carbonate; pyrographite; hydrazine hydrate; methyl iodide; In ethanol; water; ethyl acetate; acetone; acetonitrile;
DOI:10.1021/jm00067a016

Reference yield:

: 603-11-2
3-nitrophthalic acid

: 139481-56-4
3-(2'-Cyano-biphenyl-4-ylmethyl)-2-ethylamino-3H-benzoimidazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: concd. H₂SO₄ / methanol

2: SOCl₂, DMF / toluene / 0.5 h / Heating

3: NaN₃ / acetone; H₂O / 1 h

4: 1.5 h / Heating

5: 85 percent / K₂CO₃ / acetonitrile / 4 h / Heating

6: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature

7: 1.) FeCl₃*6H₂O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h

8: 96 percent / ethanol / 17 h / 50 °C

9: 1.) methyl iodide, 2.) HCl / 1.) EtOH, reflux, 24 h, 2.) EtOH, H₂O

With hydrogenchloride; thionyl chloride; sodium azide; sulfuric acid; potassium carbonate; pyrographite; hydrazine hydrate; N,N-dimethyl-formamide; methyl iodide; In methanol; ethanol; water; ethyl acetate; acetone; toluene; acetonitrile;
DOI:10.1021/jm00067a016