4-(2-amino-5-bromo-pyridin-3-yl)-2-methyl-but-3-yn-2-o

Base Information

• Chemical Name: 4-(2-amino-5-bromo-pyridin-3-yl)-2-methyl-but-3-yn-2-o
• CAS No.: 1262985-25-0
• Molecular Formula: C₁₀H₁₁BrN₂O
• Molecular Weight: 255.114
• Hs Code.: 2933399990
• Mol file: 1262985-25-0.mol

Synonyms:4-(2-amino-5-bromopyridin-3-yl)-2-methylbut-3-yn-2-ol

Chemical Property of 4-(2-amino-5-bromo-pyridin-3-yl)-2-methyl-but-3-yn-2-o

Chemical Property:

Purity/Quality:

100% ^*data from raw suppliers

4-(2-Amino-5-bromo-3-pyridinyl)-2-methyl-3-butyn-2-ol 95.26% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-amino-5-bromo-pyridin-3-yl)-2-methyl-but-3-yn-2-o

There total 2 articles about 4-(2-amino-5-bromo-pyridin-3-yl)-2-methyl-but-3-yn-2-o which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.6%

2-amino-3-iodo-5-bromopyridine (381233-96-1) + 2-methyl-but-3-yn-2-ol (115-19-5) → 4-(2-amino-5-bromopyridin-3-yl)-2-methylbut-3-yn-2-ol (1262985-25-0)

Guidance literature:

With copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; In dichloromethane; for 30h; Reagent/catalyst; Inert atmosphere; Reflux;

Reference yield:

5-bromo-2-pyridylamine (1072-97-5) → 4-(2-amino-5-bromopyridin-3-yl)-2-methylbut-3-yn-2-ol (1262985-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; sodium periodate; iodine / 2 h / 80 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; copper(l) iodide; triethylamine / dichloromethane / 30 h / Inert atmosphere; Reflux

With sodium periodate; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iodine; acetic acid; triethylamine; In dichloromethane;

Reference yield: 86.6%

4-(2-amino-5-bromopyridin-3-yl)-2-methylbut-3-yn-2-ol (1262985-25-0) → 5-bromo-1H-pyrrolo[2,3-b]pyridine (183208-35-7)

Guidance literature:

With sodium hydroxide; In water; glycerol; at 80 ℃; for 15h; Solvent;

upstream raw materials:

2-amino-3-iodo-5-bromopyridine

2-methyl-but-3-yn-2-ol

5-bromo-2-pyridylamine

Downstream raw materials:

5-bromo-1H-pyrrolo[2,3-b]pyridine

5-bromo-3-ethynyl-pyridin-2-ylamine