91230-06-7Relevant articles and documents
Ruthenium-catalyzed alkene-alkyne coupling of disubstituted olefins: Application to the stereoselective synthesis of trisubstituted enecarbamates
Trost, Barry M.,Cregg, James J.
, p. 620 - 623 (2015)
The Ru-catalyzed alkene-alkyne coupling reaction has been demonstrated to be an enabling methodology for the synthesis of complex molecules. However, to date, it has been limited to monosubstituted olefins. Herein we report the first general utilization o
Direct catalytic synthesis of unprotected 2-amino-1-phenylethanols from alkenes by using iron(II) phthalocyanine
Legnani, Luca,Morandi, Bill
supporting information, p. 2248 - 2251 (2016/02/18)
Aryl-substituted amino alcohols are privileged scaffolds in medicinal chemistry and natural products. Herein, we report that an exceptionally simple and inexpensive FeII complex efficiently catalyzes the direct transformation of simple alkenes into unprotected amino alcohols in good yield and perfect regioselectivity. This new catalytic method was applied in the expedient synthesis of bioactive molecules and could be extended to aminoetherification.
Total synthesis of pulchellalactam via an RCM strategy
Chavan, Subhash P.,Pathak, Ashok B.,Dhawane, Abasaheb N.,Kalkote
, p. 1503 - 1510 (2008/02/03)
Total synthesis of (Z) pulchellalactam, a CD protein tyrosine phosphatase inhibitor, from commercially available methallyl chloride employing ring-closure metathesis (RCM) as a key step is described. Copyright Taylor & Francis Group, LLC.
