1-O-(2-amino-2-deoxy-β-D-glucopyranosyl)-4'-O-demethyl-1-epipodophyllotoxin

Base Information

Chemical Name:1-O-(2-amino-2-deoxy-β-D-glucopyranosyl)-4'-O-demethyl-1-epipodophyllotoxin
CAS No.:111310-71-5
Molecular Formula:C₂₇H₃₁NO₁₂
Molecular Weight:561.543
Hs Code.:

Synonyms:1-O-(2-amino-2-deoxy-β-D-glucopyranosyl)-4'-O-demethyl-1-epipodophyllotoxin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-O-(2-amino-2-deoxy-β-D-glucopyranosyl)-4'-O-demethyl-1-epipodophyllotoxin

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Technology Process of 1-O-(2-amino-2-deoxy-β-D-glucopyranosyl)-4'-O-demethyl-1-epipodophyllotoxin

There total 8 articles about 1-O-(2-amino-2-deoxy-β-D-glucopyranosyl)-4'-O-demethyl-1-epipodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 99194-79-3,111322-25-9
1-O-(2-benzyloxycarbonylamino-2-deoxy-β-D-glucopyranosyl)-4'-O-benzyloxycarbonyl-4'-O-demethyl-1-epipodophyllotoxin

: 111310-71-5
1-O-(2-amino-2-deoxy-β-D-glucopyranosyl)-4'-O-demethyl-1-epipodophyllotoxin

Guidance literature:: With hydrogen; palladium; In methanol; water; for 5h;
DOI:10.1248/cpb.34.3733

Reference yield:

: 134637-16-4
C₆₄H₆₁NO₁₆

: 111310-71-5
(5R,5aR,8aR,9S)-9-((2R,3R,4R,5S,6R)-3-Amino-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; ethyl acetate; for 12h;
DOI:10.1016/S0040-4039(00)74296-1

Reference yield:

: 23363-33-9
4'-demethyl-4'-O-(benzoyloxycarbonyl)epipodophyllotoxin

: 111310-71-5
(5R,5aR,8aR,9S)-9-((2R,3R,4R,5S,6R)-3-Amino-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.25 h / -8 °C

2: H₂ / Pd(OH)2/C / methanol; ethyl acetate / 12 h

With boron trifluoride diethyl etherate; hydrogen; palladium dihydroxide; In methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4039(00)74296-1