2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetic acid

Base Information

• Chemical Name: 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetic acid
• CAS No.: 1360803-36-6
• Molecular Formula: C₂₃H₂₉NO₃
• Molecular Weight: 367.488
• Mol file: 1360803-36-6.mol

Synonyms:2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetic acid

Chemical Property of 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetic acid

There total 11 articles about 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methyl 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetate (1360803-35-5) → 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetic acid (1360803-36-6)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; for 2h;

Reference yield:

tert-butyl[(4-ethynylphenyl)methoxy]dimethylsilane (1093190-17-0) → 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetic acid (1360803-36-6)

Guidance literature:

Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 15001.5 Torr

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5.1: sodium iodide / acetone / 0.25 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol / dichloromethane / 20 h / 20 °C / Inert atmosphere

8.1: sodium hydroxide / methanol; water / 2 h / 20 °C

With n-butyllithium; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

tert-butyldimethyl((4-propylbenzyl)oxy)silane (1360803-32-2) → 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetic acid (1360803-36-6)

Guidance literature:

Multi-step reaction with 6 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3: sodium iodide / acetone / 0.25 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol / dichloromethane / 20 h / 20 °C / Inert atmosphere

6: sodium hydroxide / methanol; water / 2 h / 20 °C

With tetrabutyl ammonium fluoride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

upstream raw materials:

methyl 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetate

[2-(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)ethynyl]trimethylsilane

4-(hydroxymethyl)-1-(trimethylsilylethynyl)benzene

tert-butyl[(4-ethynylphenyl)methoxy]dimethylsilane