[2-(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)ethynyl]trimethylsilane

Base Information

• Chemical Name: [2-(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)ethynyl]trimethylsilane
• CAS No.: 1093190-16-9
• Molecular Formula: C₁₈H₃₀OSi₂
• Molecular Weight: 318.607
• Mol file: 1093190-16-9.mol

Synonyms:[2-(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)ethynyl]trimethylsilane

Chemical Property of [2-(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)ethynyl]trimethylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [2-(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)ethynyl]trimethylsilane

There total 10 articles about [2-(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)ethynyl]trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 4-(hydroxymethyl)-1-(trimethylsilylethynyl)benzene (275386-60-2) → [2-(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)ethynyl]trimethylsilane (1093190-16-9)

Guidance literature:

With 1H-imidazole; In tetrahydrofuran; at 0 - 20 ℃; for 15h; Inert atmosphere;

Reference yield: 94.0%

4-(tert-butyldimethylsiloxymethyl)bromobenzene (87736-74-1) + trimethylsilylacetylene (1066-54-2) → [2-(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)ethynyl]trimethylsilane (1093190-16-9)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); copper(l) iodide; tri-tert-butyl phosphine; triethylamine; for 20h;

DOI:10.1021/jacs.7b09390

Reference yield: 87.0%

4-(tert-butyldimethylsiloxymethyl)iodobenzene (147283-96-3) + trimethylsilylacetylene (1066-54-2) → [2-(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)ethynyl]trimethylsilane (1093190-16-9)

Guidance literature:

With copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 20 ℃; for 3h;

upstream raw materials:

4-(tert-butyldimethylsiloxymethyl)iodobenzene

trimethylsilylacetylene

tert-butyldimethylsilyl chloride

4-(hydroxymethyl)-1-(trimethylsilylethynyl)benzene

Downstream raw materials:

tert-butyl[(4-ethynylphenyl)methoxy]dimethylsilane

3-(4-(prop-1-yn-1-yl)phenyl)propionic acid ethyl ester

methyl 2-(N-(4-(prop-1-yn-1-yl)benzyl)-3-(4-(prop-1-yn-1-yl)phenyl)propanamido)acetate-d₅

2-(N-(4-(prop-1-yn-1-yl)benzyl)-3-(4-(prop-1-yn-1-yl)phenyl)propanamido)acetic acid-d5