methyl 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetate

Base Information

• Chemical Name: methyl 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetate
• CAS No.: 1360803-35-5
• Molecular Formula: C₂₄H₃₁NO₃
• Molecular Weight: 381.515
• Mol file: 1360803-35-5.mol

Synonyms:methyl 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetate

Chemical Property of methyl 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetate

There total 12 articles about methyl 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 2-((4-propylbenzyl)amino)acetate (1360803-34-4) + 2-(4-propylphenyl)acetic acid (26114-12-5) → methyl 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetate (1360803-35-5)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 20h; Inert atmosphere;

Reference yield:

4-n-propylbenzyl alcohol (82657-70-3) → methyl 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetate (1360803-35-5)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2: sodium iodide / acetone / 0.25 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol / dichloromethane / 20 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

[2-(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)ethynyl]trimethylsilane (1093190-16-9) → methyl 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetate (1360803-35-5)

Guidance literature:

Multi-step reaction with 8 steps

1.1: potassium carbonate; methanol / 2 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 15001.5 Torr

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

6.1: sodium iodide / acetone / 0.25 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol / dichloromethane / 20 h / 20 °C / Inert atmosphere

With methanol; n-butyllithium; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone;

upstream raw materials:

[2-(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)ethynyl]trimethylsilane

4-(hydroxymethyl)-1-(trimethylsilylethynyl)benzene

tert-butyl[(4-ethynylphenyl)methoxy]dimethylsilane

4-n-propylbenzyl alcohol

Downstream raw materials:

2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetic acid