(Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid N-methyl-N-ethylamide

Base Information

• Chemical Name: (Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid N-methyl-N-ethylamide
• CAS No.: 1253768-93-2
• Molecular Formula: C₁₉H₁₈N₂O₃
• Molecular Weight: 322.364

Synonyms:(Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid N-methyl-N-ethylamide

Chemical Property of (Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid N-methyl-N-ethylamide

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Technology Process of (Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid N-methyl-N-ethylamide

There total 1 articles about (Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid N-methyl-N-ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-Ethylmethylamine (624-78-2) + (Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid (1253768-91-0) → (Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid N-methyl-N-ethylamide (1253768-93-2)

Guidance literature:

(Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid; With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N-Ethylmethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1021/jm100812a

Reference yield: 54.0%

N-(4-aminophenyl)-N-methyl-methanesulfonamide (251552-20-2) + (Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid N-methyl-N-ethylamide (1253768-93-2) → (Z)-3-([4-(N-methanesulfonyl-N-methylamino)phenylamino]phenylmethylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid N-methyl-N-ethylamide

Guidance literature:

With trimethylsilylimidazole; In tetrahydrofuran; at 170 ℃; for 0.25h; Microwave irradiation;

DOI:10.1021/jm100812a

Reference yield: 50.0%

(Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid N-methyl-N-ethylamide (1253768-93-2) + 4-[2-(dimethylamino)ethyl]aniline (5636-52-2) → (Z)-3-([4-(2-(N,N-dimethylamino)ethyl)phenylamino]phenylmethylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid N-methyl-N-ethylamide

Guidance literature:

With trimethylsilylimidazole; In tetrahydrofuran; at 170 ℃; for 0.25h; Microwave irradiation;

DOI:10.1021/jm100812a

upstream raw materials:

N-Ethylmethylamine

(Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid

Downstream raw materials:

(Z)-ethyl-[4-(([6-(N-ethyl-N-methyl-carbamoyl)-2-oxo-1,2-dihydro-indol-3-ylidene]phenylmethyl)amino)benzyl]carbamic acid tert-butyl ester

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