(Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid

Base Information

Chemical Name:(Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid
CAS No.:1253768-91-0
Molecular Formula:C₁₆H₁₁NO₄
Molecular Weight:281.268
Hs Code.:

Synonyms:(Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid

Suppliers and Price of (Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of (Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid

Chemical Property:

Purity/Quality:: 95%+HPLC ^*data from raw suppliers

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Technology Process of (Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid

There total 2 articles about (Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1253768-90-9
(Z)-1-acetyl-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

: 1253768-91-0
(Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid

Guidance literature:: (Z)-1-acetyl-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester; With water; sodium hydroxide; In methanol; at 20 ℃; for 7.5h; Reflux;

With hydrogenchloride; In methanol; water; for 24h; Cooling;
DOI:10.1021/jm100812a

Reference yield:

: 14192-26-8
2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

: 1253768-91-0
(Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 6 h / 130 °C / Inert atmosphere

2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 16 h / 0 - 21 °C / Inert atmosphere

3: sodium hydroxide; water / methanol / 6 h / 21 - 100 °C

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

Reference yield: 97.0%

: 624-78-2
N-Ethylmethylamine

: 1253768-91-0
(Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid

: 1253768-93-2
(Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid N-methyl-N-ethylamide

Guidance literature:: (Z)-3-(hydroxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid; With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N-Ethylmethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1021/jm100812a