tert-butyl 5-(tert-butoxycarbonyl (2-(3-((1-tert-butoxycarbonyl)piperidin-4-yl)oxy)phenyl)pyrimidin-4-yl)amino-1H-indazole-1-carboxylate

Base Information

Chemical Name:tert-butyl 5-(tert-butoxycarbonyl (2-(3-((1-tert-butoxycarbonyl)piperidin-4-yl)oxy)phenyl)pyrimidin-4-yl)amino-1H-indazole-1-carboxylate
CAS No.:1595291-31-8
Molecular Formula:C₃₇H₄₆N₆O₇
Molecular Weight:686.808
Hs Code.:

Synonyms:tert-butyl 5-(tert-butoxycarbonyl (2-(3-((1-tert-butoxycarbonyl)piperidin-4-yl)oxy)phenyl)pyrimidin-4-yl)amino-1H-indazole-1-carboxylate

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Chemical Property of tert-butyl 5-(tert-butoxycarbonyl (2-(3-((1-tert-butoxycarbonyl)piperidin-4-yl)oxy)phenyl)pyrimidin-4-yl)amino-1H-indazole-1-carboxylate

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Technology Process of tert-butyl 5-(tert-butoxycarbonyl (2-(3-((1-tert-butoxycarbonyl)piperidin-4-yl)oxy)phenyl)pyrimidin-4-yl)amino-1H-indazole-1-carboxylate

There total 7 articles about tert-butyl 5-(tert-butoxycarbonyl (2-(3-((1-tert-butoxycarbonyl)piperidin-4-yl)oxy)phenyl)pyrimidin-4-yl)amino-1H-indazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 864136-41-4
4-[3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester

: 1595290-53-1
tert-butyl 5-((tert-butoxycarbonyl)(2-chloropyrimidin-4-yl)amino)-1H-indazole-1-carboxylate

: 1595291-31-8
tert-butyl 5-(tert-butoxycarbonyl (2-(3-((1-tert-butoxycarbonyl)piperidin-4-yl)oxy)phenyl)pyrimidin-4-yl)amino-1H-indazole-1-carboxylate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; di-tert-butyl dicarbonate; potassium acetate; In 1,4-dioxane; water; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 790667-54-8
tert-butyl 4-(3-bromophenoxy)piperidine-1-carboxylate

: 1595291-31-8
tert-butyl 5-(tert-butoxycarbonyl (2-(3-((1-tert-butoxycarbonyl)piperidin-4-yl)oxy)phenyl)pyrimidin-4-yl)amino-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 14 h / 80 °C / Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; di-tert-butyl dicarbonate; potassium acetate / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; di-tert-butyl dicarbonate; potassium acetate; In 1,4-dioxane; water;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1595291-31-8
tert-butyl 5-(tert-butoxycarbonyl (2-(3-((1-tert-butoxycarbonyl)piperidin-4-yl)oxy)phenyl)pyrimidin-4-yl)amino-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 °C / Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 14 h / 80 °C / Inert atmosphere

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; di-tert-butyl dicarbonate; potassium acetate / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; di-tert-butyl dicarbonate; potassium acetate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; water;