(4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL

Base Information

• Chemical Name: (4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL
• CAS No.: 457889-46-2
• Molecular Formula: C14H11F3O
• Molecular Weight: 252.23
• Mol file: 457889-46-2.mol

Synonyms:1-(4'-Trifluoromethylbiphenyl-4-yl)methanol;4-(Hydroxymethyl)-4'-trifluoromethylbiphenyl;

Chemical Property of (4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL

Chemical Property:

• Melting Point: 147-149 °C
• Boiling Point: 332.18 °C at 760 mmHg
• Flash Point: 136.784 °C
• PSA: 20.23000
• Density: 1.248 g/cm³
• LogP: 3.86470
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

[4'-(Trifluoromethyl)[1,1'-biphenyl]-4-yl]methanol >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL

There total 10 articles about (4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-bromobenzenemethanol (873-75-6) + 4-trifluoromethylphenylboronic acid (128796-39-4) → (4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol (457889-46-2)

Guidance literature:

With tetrabutylammomium bromide; palladium diacetate; sodium carbonate; In water; at 150 ℃; for 0.333333h; Sealed tube;

Reference yield: 95.0%

ethyl 4'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate (647842-34-0) → (4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol (457889-46-2)

Guidance literature:

ethyl 4'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃;

With ammonium chloride; In tetrahydrofuran; Saturated solution;

Reference yield: 93.0%

methyl 4’-(trifluoromethyl)-[1,1’-biphenyl]-4-carboxylate (127783-73-7) → (4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol (457889-46-2)

Guidance literature:

methyl 4’-(trifluoromethyl)-[1,1’-biphenyl]-4-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.166667h;

With potassium hydrogensulfate; water; ethyl acetate; In tetrahydrofuran; at 0 ℃;

upstream raw materials:

p-trifluoromethylphenyl bromide

p-hydroxymethylphenylboronic acid

4-(4-trifluoromethylphenyl)benzaldehyde

methyl 4’-(trifluoromethyl)-[1,1’-biphenyl]-4-carboxylate

Downstream raw materials:

1-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole

methyl 3-((tert-butoxycarbonylamino)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazole-5-carboxylate

methyl 3-((4-oxo-2-thioxo-2,3,4,5,6,7-hexahydro-1H-cyclopenta[d]pyrimidin-1-yl)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazole-5-carboxylate

methyl 3-((2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)methyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)isoxazole-5-carboxylate