2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenol

Base Information

Chemical Name:2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenol
CAS No.:1030367-87-3
Molecular Formula:C₂₈H₂₃F₃OS
Molecular Weight:464.551
Hs Code.:

Synonyms:2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenol

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Technology Process of 2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenol

There total 5 articles about 2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1030367-81-7
tert-butyl dimethyl(2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenoxy)silane

: 1030367-87-3
2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2018.06.044

Reference yield:

: 454464-38-1
4-Chloromethyl-4'-trifluoromethyl-biphenyl

: 1030367-87-3
2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

1.2: 0.17 h / -78 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 25 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C

3.2: 0.5 h / -78 - 25 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 25 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; isopropylmagnesium chloride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1030367-79-3
2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenol

: 1030367-87-3
2-methyl-4-((2-phenyl-1-(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)ethyl)thio)phenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 25 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C

2.2: 0.5 h / -78 - 25 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 25 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;