Methyl 4-[(4E)-3-[4-(1H-tetrazol-5-yl)benzyl]-5-(2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-phenyl)pent-4-en-1-yl]benzoate

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Chemical Name:Methyl 4-[(4E)-3-[4-(1H-tetrazol-5-yl)benzyl]-5-(2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-phenyl)pent-4-en-1-yl]benzoate
CAS No.:935253-34-2
Molecular Formula:C₄₁H₃₅F₃N₄O₃
Molecular Weight:688.749
Hs Code.:

Synonyms:Methyl 4-[(4E)-3-[4-(1H-tetrazol-5-yl)benzyl]-5-(2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-phenyl)pent-4-en-1-yl]benzoate

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Chemical Property of Methyl 4-[(4E)-3-[4-(1H-tetrazol-5-yl)benzyl]-5-(2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-phenyl)pent-4-en-1-yl]benzoate

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Technology Process of Methyl 4-[(4E)-3-[4-(1H-tetrazol-5-yl)benzyl]-5-(2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-phenyl)pent-4-en-1-yl]benzoate

There total 13 articles about Methyl 4-[(4E)-3-[4-(1H-tetrazol-5-yl)benzyl]-5-(2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-phenyl)pent-4-en-1-yl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 934753-43-2
methyl 4-[(4E)-3-(4-cyanobenzyl)-5-(2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)pent-4-en-1-yl]benzoate

: 935253-34-2
Methyl 4-[(4E)-3-[4-(1H-tetrazol-5-yl)benzyl]-5-(2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-phenyl)pent-4-en-1-yl]benzoate

Guidance literature:: With trimethylsilylazide; di(n-butyl)tin oxide; In toluene; at 80 ℃;

Reference yield:

: 5798-75-4
Ethyl 4-bromobenzoate

: 935253-34-2
Methyl 4-[(4E)-3-[4-(1H-tetrazol-5-yl)benzyl]-5-(2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-phenyl)pent-4-en-1-yl]benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / Inert atmosphere; Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

3: thionyl chloride / chloroform / 20 °C

4: potassium carbonate / acetonitrile / Reflux

5: trimethylsilylazide; di(n-butyl)tin oxide / toluene / 80 °C

With lithium aluminium tetrahydride; thionyl chloride; trimethylsilylazide; di(n-butyl)tin oxide; sodium carbonate; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; chloroform; water; toluene; acetonitrile;

Reference yield:

: 934738-13-3
diallyl 2-(4-cyanobenzyl)malonate

: 935253-34-2
Methyl 4-[(4E)-3-[4-(1H-tetrazol-5-yl)benzyl]-5-(2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}-phenyl)pent-4-en-1-yl]benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

1.2: 0 - 20 °C

2.1: formic acid; triethylamine; triphenylphosphine / palladium diacetate / 1,4-dioxane / 20 - 100 °C

3.1: borane-THF / tetrahydrofuran / -10 - -5 °C

4.1: pyridinium chlorochromate / dichloromethane / 20 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 0 - 20 °C

6.1: potassium carbonate / acetonitrile / Reflux

7.1: trimethylsilylazide; di(n-butyl)tin oxide / toluene / 80 °C

With n-butyllithium; formic acid; borane-THF; trimethylsilylazide; sodium hydride; di(n-butyl)tin oxide; potassium carbonate; triethylamine; triphenylphosphine; pyridinium chlorochromate; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;