2-(4-chlorophenyl)-4-methyl1-[4-(methylsulfonyl)phenyl]-4-hydroxy-4,5-dihydro-1H-imidazole

Base Information

• Chemical Name: 2-(4-chlorophenyl)-4-methyl1-[4-(methylsulfonyl)phenyl]-4-hydroxy-4,5-dihydro-1H-imidazole
• CAS No.: 1027164-88-0
• Molecular Formula: C₁₇H₁₇ClN₂O₃S
• Molecular Weight: 364.853

Synonyms:2-(4-chlorophenyl)-4-methyl1-[4-(methylsulfonyl)phenyl]-4-hydroxy-4,5-dihydro-1H-imidazole

Chemical Property of 2-(4-chlorophenyl)-4-methyl1-[4-(methylsulfonyl)phenyl]-4-hydroxy-4,5-dihydro-1H-imidazole

Chemical Property:

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Technology Process of 2-(4-chlorophenyl)-4-methyl1-[4-(methylsulfonyl)phenyl]-4-hydroxy-4,5-dihydro-1H-imidazole

There total 4 articles about 2-(4-chlorophenyl)-4-methyl1-[4-(methylsulfonyl)phenyl]-4-hydroxy-4,5-dihydro-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-N-[4-(methylsulfonyl)phenyl]benzenecarboximidamide (177662-23-6) → 2-(4-chlorophenyl)-4-methyl1-[4-(methylsulfonyl)phenyl]-4-hydroxy-4,5-dihydro-1H-imidazole (1027164-88-0)

Guidance literature:

With sodium hydrogencarbonate; In isopropyl alcohol; at 78 - 80 ℃; for 20h; Heating;

DOI:10.1021/jm9700225

Reference yield:

4-Cyanochlorobenzene (623-03-0) → 2-(4-chlorophenyl)-4-methyl1-[4-(methylsulfonyl)phenyl]-4-hydroxy-4,5-dihydro-1H-imidazole (1027164-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trimethylaluminum / 1.) toluene, a) 0 deg C - RT, b) RT, 3.5 h, 2.) toluene, 70 deg C - 75 deg C, 17 h

2: sodium hydrogencarbonate / isopropyl alcohol / 20 h / 78 - 80 °C / Heating

With trimethylaluminum; sodium hydrogencarbonate; In isopropyl alcohol;

DOI:10.1021/jm9700225

Reference yield:

4-methanesulfonylphenylamine (5470-49-5) → 2-(4-chlorophenyl)-4-methyl1-[4-(methylsulfonyl)phenyl]-4-hydroxy-4,5-dihydro-1H-imidazole (1027164-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trimethylaluminum / 1.) toluene, a) 0 deg C - RT, b) RT, 3.5 h, 2.) toluene, 70 deg C - 75 deg C, 17 h

2: sodium hydrogencarbonate / isopropyl alcohol / 20 h / 78 - 80 °C / Heating

With trimethylaluminum; sodium hydrogencarbonate; In isopropyl alcohol;

DOI:10.1021/jm9700225

upstream raw materials:

4-chloro-N-[4-(methylsulfonyl)phenyl]benzenecarboximidamide

4-Cyanochlorobenzene

4-methanesulfonylphenylamine

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