TRANS-5-TRIMETHYLSILYL-2-PENTEN-4-YN-1-OL

Base Information

• Chemical Name: TRANS-5-TRIMETHYLSILYL-2-PENTEN-4-YN-1-OL
• CAS No.: 97514-97-1
• Molecular Formula: C8H14 O Si
• Molecular Weight: 154.284
• Hs Code.: 2931900090
• Mol file: 97514-97-1.mol

Synonyms:2-Penten-4-yn-1-ol,5-(trimethylsilyl)-, (E)-; (E)-1-(Trimethylsilyl)-2-penten-4-yn-1-ol

Chemical Property of TRANS-5-TRIMETHYLSILYL-2-PENTEN-4-YN-1-OL

Chemical Property:

• PSA: 20.23000
• LogP: 1.41570

Purity/Quality:

99% ^*data from raw suppliers

trans-5-(Trimethylsilyl)-2-penten-4-yn-1-ol 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TRANS-5-TRIMETHYLSILYL-2-PENTEN-4-YN-1-OL

There total 11 articles about TRANS-5-TRIMETHYLSILYL-2-PENTEN-4-YN-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl 3-(trimethylsilyl)propynoate (16205-84-8) → (E)-5-trimethylsilanylpent-2-en-4-yn-1-ol (97514-97-1)

Guidance literature:

With diisobutylaluminium hydride; In diethyl ether; hexane; at -78 - 0 ℃; for 2h;

DOI:10.1002/chem.201202701

Reference yield: 92.0%

chloro-trimethyl-silane (75-77-4) + (E)-2-penten-4-yn-1-ol (35042-52-5) → (E)-5-trimethylsilanylpent-2-en-4-yn-1-ol (97514-97-1)

Guidance literature:

With ethylmagnesium bromide; In tetrahydrofuran; at 50 ℃;

DOI:10.1021/ja00311a048

Reference yield: 92.0%

ethyl (2E)-5-trimethylsilyl-pent-2-en-4-ynoate (54599-61-0) → (E)-5-trimethylsilanylpent-2-en-4-yn-1-ol (97514-97-1)

Guidance literature:

With diisobutylaluminium hydride; In hexane; at -78 ℃; for 0.5h;

DOI:10.1021/ja055967n

upstream raw materials:

chloro-trimethyl-silane

(E)-2-penten-4-yn-1-ol

(2E)-3-iodo-2-propen-1-ol

trimethylsilylacetylene

Downstream raw materials:

(E)-5-(trimethylsilyl)pent-2-en-4-ynyl (toluene-4-sulfonyl)acetate

(R,4Z,6Z,8E)-3-hydroxy-2,2,4-trimethyl-10-(oxazol-5-yl)deca-4,6,8-trienamide

(7E,9E,11E,13E)-(5R,6S,15S)-5,6,15-Trihydroxy-icosa-7,9,11,13-tetraenoic acid

(7E,9E,11Z,13E)-(5R,6S,15S)-5,6,15-Trihydroxy-icosa-7,9,11,13-tetraenoic acid

Refernces

• 1、 Kumar, Manjeet,Bromhead, Liam,Anderson, Zoe,Overy, Alistair,Burton, Jonathan W.. "Short, Tin-Free Synthesis of All Three Inthomycins". supporting information. p. 16753 - 16756. Retrieved 2018/10/26.
• 2、 Ng, Pearly Shuyi,Bates, Roderick W.. "Synthesis of hydroxylated pyrrolidines by allenic cyclisation". . p. 6356 - 6362. Retrieved 2016/09/23.