9-(1,1'-biphenyl-4-yl)-7-phenyl-2-(2-thienyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine

Base Information

Chemical Name:9-(1,1'-biphenyl-4-yl)-7-phenyl-2-(2-thienyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
CAS No.:1448231-49-9
Molecular Formula:C₂₈H₁₈N₆S
Molecular Weight:470.557
Hs Code.:

Synonyms:9-(1,1'-biphenyl-4-yl)-7-phenyl-2-(2-thienyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine

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Chemical Property of 9-(1,1'-biphenyl-4-yl)-7-phenyl-2-(2-thienyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine

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Technology Process of 9-(1,1'-biphenyl-4-yl)-7-phenyl-2-(2-thienyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine

There total 9 articles about 9-(1,1'-biphenyl-4-yl)-7-phenyl-2-(2-thienyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1448231-43-3
9-(1,1'-biphenyl-4-yl)-7-phenyl-3-(2-thienyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine

: 1448231-49-9
9-(1,1'-biphenyl-4-yl)-7-phenyl-2-(2-thienyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine

Guidance literature:: With sodium acetate; In ethanol; for 6h; Reflux;
DOI:10.3184/174751913X13570601346457

Reference yield:

: 1448231-28-4
5-amino-3-(1,1-biphenyl-4-yl)-1-phenyl-1H-pyrazole-4-carbonitrile

: 1448231-49-9
9-(1,1'-biphenyl-4-yl)-7-phenyl-2-(2-thienyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: acetic anhydride / 7 h / Reflux

2: hydrazine hydrate / ethanol / 3 h / Reflux

3: acetic acid / ethanol / 2 h / Reflux

4: iron(III) chloride / ethanol / 12 h / 45 °C

5: sodium acetate / ethanol / 6 h / Reflux

With iron(III) chloride; hydrazine hydrate; sodium acetate; acetic anhydride; acetic acid; In ethanol; 5: |Dimroth Rearrangement;
DOI:10.3184/174751913X13570601346457

Reference yield:

: 100-63-0
phenylhydrazine

: 1448231-49-9
9-(1,1'-biphenyl-4-yl)-7-phenyl-2-(2-thienyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine / 3.5 h

2: tetrachloromethane; triphenylphosphine / acetonitrile / 14 h / 20 °C / Reflux

3: sodium ethanolate / ethanol

4: acetic anhydride / 7 h / Reflux

5: hydrazine hydrate / ethanol / 3 h / Reflux

6: acetic acid / ethanol / 2 h / Reflux

7: iron(III) chloride / ethanol / 12 h / 45 °C

8: sodium acetate / ethanol / 6 h / Reflux

With pyridine; tetrachloromethane; iron(III) chloride; hydrazine hydrate; sodium ethanolate; sodium acetate; acetic anhydride; acetic acid; triphenylphosphine; In ethanol; acetonitrile; 8: |Dimroth Rearrangement;
DOI:10.3184/174751913X13570601346457