5-(hydroxymethylene)-2-(p-methylbenzyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one

Base Information

Chemical Name:5-(hydroxymethylene)-2-(p-methylbenzyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one
CAS No.:1148040-74-7
Molecular Formula:C₁₇H₁₇NO₂
Molecular Weight:267.327
Hs Code.:

Synonyms:5-(hydroxymethylene)-2-(p-methylbenzyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one

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Chemical Property of 5-(hydroxymethylene)-2-(p-methylbenzyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one

Chemical Property:

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Technology Process of 5-(hydroxymethylene)-2-(p-methylbenzyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one

There total 1 articles about 5-(hydroxymethylene)-2-(p-methylbenzyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1148040-69-0
2-(p-methylbenzyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one

: 109-94-4
formic acid ethyl ester

: 1148040-74-7
5-(hydroxymethylene)-2-(p-methylbenzyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one

Guidance literature:: 2-(p-methylbenzyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one; With potassium tert-butylate; In benzene; at 0 - 20 ℃;

formic acid ethyl ester; In benzene; at 0 - 20 ℃; for 24h;
DOI:10.1016/j.bmcl.2009.01.096

Reference yield: 60.0%

: 1148040-74-7
5-(hydroxymethylene)-2-(p-methylbenzyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one

: 57-13-6
urea

: 1575821-55-4
8-(4-methylbenzyl)-3,5,6,8-tetrahydro-2H-pyrrolo[3,4-h]quinazolin-2-one

Guidance literature:: In ethanol; for 24h; Inert atmosphere; Reflux;
DOI:10.1016/j.ejmech.2013.10.014

Reference yield:

: 1148040-74-7
5-(hydroxymethylene)-2-(p-methylbenzyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one

: 1575821-71-4
8-(4-methylbenzyl)-6,8-dihydro-5H-pyrrolo[3,4-h]quinazolin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 24 h / 20 °C

2: sodium methylate / ethanol / 4 h / Reflux

With sodium methylate; In ethanol; toluene;
DOI:10.1016/j.ejmech.2013.10.014