N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-5-chloropyridine

Base Information

Chemical Name:N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-5-chloropyridine
CAS No.:1600518-03-3
Molecular Formula:C₂₃H₂₁ClN₂O₄S
Molecular Weight:456.95
Hs Code.:

Synonyms:N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-5-chloropyridine

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Chemical Property of N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-5-chloropyridine

Chemical Property:

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Technology Process of N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-5-chloropyridine

There total 4 articles about N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-5-chloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 626-60-8
3-Chloropyridine

: 541-41-3
chloroformic acid ethyl ester

: 312329-87-6
N-ethynyl-N-phenyl-4-methyl-benzenesulfonamide

: 1600518-03-3
N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-5-chloropyridine

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 2.5h; regioselective reaction; Inert atmosphere;
DOI:10.1021/jo500365h

Reference yield:

: 68-34-8
phenyl toluenesulfonamide

: 1600518-03-3
N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-5-chloropyridine

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexyl-carbodiimide

2: triphenylphosphine

3: n-butyllithium

4: copper(l) iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 2.5 h / 25 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; triphenylphosphine; In dichloromethane;
DOI:10.1021/jo500365h

Reference yield:

: 68984-88-3
N-Formyl-N-phenyl-4-methyl-benzenesulfonamide

: 1600518-03-3
N-ethoxycarbonyl-1,2-dihydro-2-(N-phenyl-N-tosylaminoethynyl)-5-chloropyridine

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine

2: n-butyllithium

3: copper(l) iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 2.5 h / 25 °C / Inert atmosphere

With copper(l) iodide; n-butyllithium; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane;
DOI:10.1021/jo500365h