1-(BENZYLOXY)-1H-IMIDAZOLE

Base Information

• Chemical Name: 1-(BENZYLOXY)-1H-IMIDAZOLE
• CAS No.: 121779-19-9
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.2
• Mol file: 121779-19-9.mol

Synonyms:1-(Benzyloxy)-1H-imidazole;

Chemical Property of 1-(BENZYLOXY)-1H-IMIDAZOLE

Chemical Property:

• Melting Point: 31-33 °C
• Boiling Point: 312.9 °C at 760 mmHg
• PKA: 4.76±0.10(Predicted)
• Flash Point: 143.1 °C
• PSA: 27.05000
• Density: 1.09 g/cm³
• LogP: 1.51190
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-(Benzyloxy)-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(BENZYLOXY)-1H-IMIDAZOLE

There total 6 articles about 1-(BENZYLOXY)-1H-IMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

benzyl bromide (100-39-0) + trans-hydroxy imidazole (45376-79-2) → 1-(benzyloxy)imidazole (121779-19-9)

Guidance literature:

With tetra(n-butyl)ammonium hydroxide; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1055/s-1989-27392

Reference yield:

1-benzyloxyimidazole 3-oxide (1027036-69-6) → 1-(benzyloxy)imidazole (121779-19-9)

Guidance literature:

With phosphorus trichloride; In chloroform; for 1.5h; Heating;

DOI:10.1021/jo970355+

Reference yield:

benzyl bromide (100-39-0) → 1-(benzyloxy)imidazole (121779-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) potassium hydroxide / 1.) methanol, 2.) methanol, reflux, 1 h

2: 12.0 g / phosphorous trichloride / CHCl₃ / 1.5 h / Heating

With potassium hydroxide; phosphorus trichloride; In chloroform;

DOI:10.1021/jo970355+

upstream raw materials:

benzyl bromide

trans-hydroxy imidazole

1H-imidazole

benzyl chloride

Downstream raw materials:

1-benzyloxy-2-chloromethyl-1H-imidazole

1-benzyloxy-2-hydroxymethylimidazole

1-(benzyloxy)-5-formylmidazole

1-Benzyloxy-2-(tert-butyl-dimethyl-silanyl)-1H-imidazole

Refernces

• 1、 Laus, Gerhard,Schwaerzler, Alexander,Bentivoglio, Gino,Hummel, Michael,Kahlenberg, Volker,Wurst, Klaus,Kristeva, Elka,Schuetz, Johannes,Kopacka, Holger,Kreutz, Christoph,Bonn, Guenther,Andriyko, Yuriy,Nauer, Gerhard,Schottenberger, Herwig. "Synthesis and crystal structures of 1-alkoxy-3-alkylimidazolium salts including ionic liquids, 1-alkylimidazole 3-oxides and 1-alkylimidazole perhydrates". experimental part. p. 447 - 464. Retrieved 2009/01/31.
• 2、 Begtrup, Mikael,Vedso, Per. "Preparation of N-Hydroxyazoles by Oxidation of Azoles". . p. 243 - 248. Retrieved 2007/10/02.