6-oxo-6-p-tolylhexanoic acid methyl ester

Base Information

• Chemical Name: 6-oxo-6-p-tolylhexanoic acid methyl ester
• CAS No.: 91202-39-0
• Molecular Formula: C₁₄H₁₈O₃
• Molecular Weight: 234.295
• Mol file: 91202-39-0.mol

Synonyms:6-oxo-6-p-tolylhexanoic acid methyl ester

Chemical Property of 6-oxo-6-p-tolylhexanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-oxo-6-p-tolylhexanoic acid methyl ester

There total 8 articles about 6-oxo-6-p-tolylhexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(p-toluoyl)valeric acid (100847-96-9) + diazomethyl-trimethyl-silane (18107-18-1) → 6-oxo-6-p-tolylhexanoic acid methyl ester (91202-39-0)

Guidance literature:

In methanol; hexane; benzene; at 20 ℃; for 1h;

DOI:10.1021/ja808829t

Reference yield:

para-bromotoluene (106-38-7) → 6-oxo-6-p-tolylhexanoic acid methyl ester (91202-39-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) magnesium; 2.) toluenesulfonic acid / 1.) tetrahydrofuran, reflux, 2.5 h; 2.) toluene

2: 1.) O₃; 2.) sulfuric acid / 1.) 20 min; 2.) 30 min, reflux

With sulfuric acid; o-toluenesulfonic acid; ozone; magnesium;

DOI:10.1021/ja00331a041

Reference yield:

adipic anhydride (2035-75-8) → 6-oxo-6-p-tolylhexanoic acid methyl ester (91202-39-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 18 g / AlCl₃ / toluene / 12 h / Ambient temperature

2: H₂SO₄ / methanol

With aluminium trichloride; sulfuric acid; In methanol; toluene;

upstream raw materials:

methanol

1-cyclohex-1-enyl-4-methylbenzene

5-(p-toluoyl)valeric acid

methyl adipoyl chloride

Downstream raw materials:

6-hydroxy-6-(4-methylbenzoyl)heptanoic acid

6-(4-Bromomethyl-phenyl)-6-oxo-hexanoic acid methyl ester

6-(4-Methyl-3-nitro-phenyl)-heptanoic acid

6-(3-methoxy-4-methylphenyl)heptanoic acid

Refernces

• 1、 Miyamoto, Kazunori,Ochiai, Masahito,Sei, Yoshihisa,Yamaguchi, Kentaro. "Lodomesitylene-catalyzed oxidative cleavage of carbon-carbon double and triple bonds using m-chloroperbenzoic acid as a terminal oxidant". supporting information; experimental part. p. 1382 - 1383. Retrieved 2009/07/24.
• 2、 Mooney, William F.,Brown, Patti E.,Russell, John C.,Costa, Silvia B.,Pedersen, Lee G.,Whitten, David G.. "Photochemistry and Photophysics of Surfactant trans-Stilbenes in Supported Multilayers and Films at the Air-Water Interface". . p. 5659 - 5667. Retrieved 2007/10/02.