100847-96-9Relevant articles and documents
Selective C-C Bond Cleavage of Cycloalkanones by NaNO2/HCl
He, Tianyu,Chen, Dengfeng,Qian, Shencheng,Zheng, Yu,Huang, Shenlin
, p. 6525 - 6529 (2021/09/02)
A novel selective fragmentation of cycloalkanones by NaNO2/HCl has been established. The C-C bond cleavage reaction proceeds smoothly under mild conditions, selectively affording versatile keto acids or oxime acids. The methodology can streamline the synthesis of valuable chiral molecules and isocoumarins from readily available feedstocks.
Solid-supported cross-metathesis and a formal alkane metathesis for the generation of biologically relevant molecules
Mndez, Luciana,Mata, Ernesto G.
, p. 81 - 86 (2015/08/18)
Solid-phase synthetic strategies toward the generation of libraries of biologically relevant molecules were developed using olefin cross-metathesis as a key step. It is remarkably the formal alkane metathesis based on a one-pot, microwave-assisted, ruthenium-catalyzed cross-metathesis and reduction to obtain Csp3-Csp3 linkages.
Alkylarylketo acids
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, (2008/06/13)
Disclosed are novel alkylarylketocarboxylic acids and 5-substituted tetrazoles represented by the formula STR1 wherein Z is aryl or an alkyl of the structure STR2 W is a carboxyl moiety or a tetrazole moiety bound to Z at the 5-position of the tetrazole; R1 is C4 -C12 alkyl where Z is aryl and X is oxygen or is C5 -C12 alkyl where Z is alkyl and where Z is aryl and X is a bond; R2 and R3 are each independently hydrogen, C1 -C4 alkyl, hydroxy, C1 -C4 alkoxy, halogen, trihalomethyl, nitro, cyano or C1 -C4 acyl; R4, R5, R6 and R7 are each independently hydrogen or C1 -C4 alkyl or R4 and R6 or R5 and R7 can combine to form a carbocyclic ring; X is oxygen, or a bond at the ortho or para position; m is 0, 1 or 2; and n is 0 or 1, and nontoxic, pharmaceutically acceptable addition salts and carboxylic acid esters thereof.
