2,8-dibromo-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin

Base Information

• Chemical Name: 2,8-dibromo-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin
• CAS No.: 1279129-77-9
• Molecular Formula: C₃₂H₃₇BBr₂
• Molecular Weight: 592.265
• Mol file: 1279129-77-9.mol

Synonyms:2,8-dibromo-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin

Chemical Property of 2,8-dibromo-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,8-dibromo-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin

There total 8 articles about 2,8-dibromo-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,8-dibromo-5,5-dimethyldibenzo[b,f]stannepin (1279129-79-1) + 2,4,6-tri-tert-butylphenyllithium (35383-91-6) → 2,8-dibromo-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin (1279129-77-9)

Guidance literature:

2,8-dibromo-5,5-dimethyldibenzo[b,f]stannepin; With boron trichloride; In hexane; toluene; at -78 - 20 ℃; for 1h; Inert atmosphere;

2,4,6-tri-tert-butylphenyllithium; In hexane; toluene; at 20 ℃; for 18h;

Reference yield:

2-methyl-4-bromoiodobenzene (116632-39-4) → 2,8-dibromo-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin (1279129-77-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 1,2-dichloro-ethane / 20 °C / Inert atmosphere

1.2: 5 h / Reflux

2.1: N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.2: 18 h / 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.2: 24 h / 0 - 20 °C

4.1: n-butyllithium / hexane; diethyl ether / 0.17 h / -78 °C / Inert atmosphere

4.2: 2 h / -78 °C

4.3: 18 h / 20 °C

5.1: boron trichloride / toluene; hexane / 1 h / -78 - 20 °C / Inert atmosphere

5.2: 18 h / 20 °C

With n-butyllithium; potassium tert-butylate; boron trichloride; In tetrahydrofuran; diethyl ether; hexane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

4-bromo-2-(bromomethyl)-1-iodobenzene (495414-06-7) → 2,8-dibromo-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin (1279129-77-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 20 °C / Inert atmosphere

1.2: 18 h / 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 24 h / 0 - 20 °C

3.1: n-butyllithium / hexane; diethyl ether / 0.17 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 °C

3.3: 18 h / 20 °C

4.1: boron trichloride / toluene; hexane / 1 h / -78 - 20 °C / Inert atmosphere

4.2: 18 h / 20 °C

With n-butyllithium; potassium tert-butylate; boron trichloride; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

2,8-dibromo-5,5-dimethyldibenzo[b,f]stannepin

2,4,6-tri-tert-butylphenyllithium

5-bromo-2-iodobenzaldehyde

4-bromo-2-(bromomethyl)-1-iodobenzene

Downstream raw materials:

2,8-diethynyl-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin

5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin-2,8-dicarboxylic acid

2,8-di(thiophen-2-yl)-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin

2,8-bis(diphenylamino)-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin