Technology Process of 5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin-2,8-dicarboxylic acid
There total 9 articles about 5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin-2,8-dicarboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,8-dibromo-5-(2,4,6-tri-tert-butylphenyl)dibenzo[b,f]borepin;
With
sec.-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
Inert atmosphere;
carbon dioxide;
In
tetrahydrofuran; toluene;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1021/jo2001726
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: boron trichloride / hexane; toluene / 1 h / -78 - 20 °C / Inert atmosphere
2.1: hexane; toluene / 18 h / 20 °C / Inert atmosphere
3.1: sec.-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
3.2: -78 - 20 °C / Inert atmosphere
With
sec.-butyllithium; boron trichloride;
In
tetrahydrofuran; hexane; toluene;
DOI:10.1021/jo2001726
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 1,2-dichloro-ethane / 20 °C / Inert atmosphere
1.2: 5 h / Reflux
2.1: N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2.2: 18 h / 20 °C
3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
3.2: 24 h / 0 - 20 °C
4.1: n-butyllithium / hexane; diethyl ether / 0.17 h / -78 °C / Inert atmosphere
4.2: 2 h / -78 °C
4.3: 18 h / 20 °C
5.1: boron trichloride / toluene; hexane / 1 h / -78 - 20 °C / Inert atmosphere
5.2: 18 h / 20 °C
6.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
6.2: 18 h / 20 °C
With
n-butyllithium; potassium tert-butylate; boron trichloride;
In
tetrahydrofuran; diethyl ether; hexane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
