t-butyl 2-methyl-5-benzylcarbonyloxyamino-6-oxo-1,6-dihydro-1-pyrimidinylacetate

Base Information

Chemical Name:t-butyl 2-methyl-5-benzylcarbonyloxyamino-6-oxo-1,6-dihydro-1-pyrimidinylacetate
CAS No.:179524-44-8
Molecular Formula:C₁₈H₂₃N₃O₅S
Molecular Weight:393.464
Hs Code.:

Synonyms:t-butyl 2-methyl-5-benzylcarbonyloxyamino-6-oxo-1,6-dihydro-1-pyrimidinylacetate

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Chemical Property of t-butyl 2-methyl-5-benzylcarbonyloxyamino-6-oxo-1,6-dihydro-1-pyrimidinylacetate

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Technology Process of t-butyl 2-methyl-5-benzylcarbonyloxyamino-6-oxo-1,6-dihydro-1-pyrimidinylacetate

There total 6 articles about t-butyl 2-methyl-5-benzylcarbonyloxyamino-6-oxo-1,6-dihydro-1-pyrimidinylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 179524-43-7
t-butyl 2-methyl-5-amino-6-oxo-1,6-dihydro-1-pyrimidinylacetate

: 1939-99-7
benzenesulfonyl chloride

: 179524-44-8
t-butyl 2-methyl-5-benzylcarbonyloxyamino-6-oxo-1,6-dihydro-1-pyrimidinylacetate

Guidance literature:: With 4-methyl-morpholine; potassium carbonate; In methanol; water;
DOI:10.1016/S0960-894X(97)00258-8

Reference yield:

: 53135-24-3
ethyl 3,4-dihydro-4-oxo-2-methylpyrimidine-5-carboxylate

: 179524-44-8
t-butyl 2-methyl-5-benzylcarbonyloxyamino-6-oxo-1,6-dihydro-1-pyrimidinylacetate

Guidance literature:: Multi-step reaction with 5 steps

1: 45 percent / TBAF / 1,2-dimethoxy-ethane

2: 67 percent / LiOH

3: 1.) DPPA, Et₃N / 1.) dioxane, 110 deg C, 2.) 110 deg C

4: 100 percent / H₂ / Pd/C / ethanol

5: 82 percent / NMM, K₂CO₃ / methanol; H₂O

With 4-methyl-morpholine; lithium hydroxide; diphenyl-phosphinic acid; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; ethanol; water;
DOI:10.1016/S0960-894X(97)00258-8

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 179524-44-8
t-butyl 2-methyl-5-benzylcarbonyloxyamino-6-oxo-1,6-dihydro-1-pyrimidinylacetate

Guidance literature:: Multi-step reaction with 5 steps

1: 45 percent / TBAF / 1,2-dimethoxy-ethane

2: 67 percent / LiOH

3: 1.) DPPA, Et₃N / 1.) dioxane, 110 deg C, 2.) 110 deg C

4: 100 percent / H₂ / Pd/C / ethanol

5: 82 percent / NMM, K₂CO₃ / methanol; H₂O

With 4-methyl-morpholine; lithium hydroxide; diphenyl-phosphinic acid; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; ethanol; water;
DOI:10.1016/S0960-894X(97)00258-8