1-benzyloxy-2,5-di(tert-butyl)-3-ethoxycarbonyl-4-formylpyrrole

Base Information

• Chemical Name: 1-benzyloxy-2,5-di(tert-butyl)-3-ethoxycarbonyl-4-formylpyrrole
• CAS No.: 1609120-56-0
• Molecular Formula: C₂₃H₃₁NO₄
• Molecular Weight: 385.503
• Mol file: 1609120-56-0.mol

Synonyms:1-benzyloxy-2,5-di(tert-butyl)-3-ethoxycarbonyl-4-formylpyrrole

Chemical Property of 1-benzyloxy-2,5-di(tert-butyl)-3-ethoxycarbonyl-4-formylpyrrole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyloxy-2,5-di(tert-butyl)-3-ethoxycarbonyl-4-formylpyrrole

There total 3 articles about 1-benzyloxy-2,5-di(tert-butyl)-3-ethoxycarbonyl-4-formylpyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

1-benzyloxy-2,5-di(tert-butyl)-3-ethoxycarbonylpyrrole (1609120-55-9) + N-methyl-N-phenylformamide (93-61-8) → 1-benzyloxy-2,5-di(tert-butyl)-3-ethoxycarbonyl-4-formylpyrrole (1609120-56-0)

Guidance literature:

N-methyl-N-phenylformamide; With trichlorophosphate; In neat (no solvent); for 0.25h; Cooling with ice;

1-benzyloxy-2,5-di(tert-butyl)-3-ethoxycarbonylpyrrole; With sodium acetate; In neat (no solvent); at 20 - 50 ℃; for 3h;

With water; sodium acetate; at 50 ℃;

DOI:10.1016/j.tetlet.2014.04.004

Reference yield:

benzyl bromide (100-39-0) → 1-benzyloxy-2,5-di(tert-butyl)-3-ethoxycarbonyl-4-formylpyrrole (1609120-56-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C

2.1: trichlorophosphate / neat (no solvent) / 0.25 h / Cooling with ice

2.2: 255 / 3 h / 20 - 50 °C

2.3: 50 °C

With potassium carbonate; trichlorophosphate; In dimethyl sulfoxide;

DOI:10.1016/j.tetlet.2014.04.004

Reference yield:

1-hydroxy-2,5-di(tert-butyl)-3-ethoxycarbonylpyrrole (30723-03-6) → 1-benzyloxy-2,5-di(tert-butyl)-3-ethoxycarbonyl-4-formylpyrrole (1609120-56-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C

2.1: trichlorophosphate / neat (no solvent) / 0.25 h / Cooling with ice

2.2: 255 / 3 h / 20 - 50 °C

2.3: 50 °C

With potassium carbonate; trichlorophosphate; In dimethyl sulfoxide;

DOI:10.1016/j.tetlet.2014.04.004

upstream raw materials:

benzyl bromide

1-benzyloxy-2,5-di(tert-butyl)-3-ethoxycarbonylpyrrole

N-methyl-N-phenylformamide

1-hydroxy-2,5-di(tert-butyl)-3-ethoxycarbonylpyrrole

Downstream raw materials:

1-benzyloxy-2,5-di-(tert-butyl)-3-ethoxycarbonyl-4-formyloxypyrrole