1-benzyloxy-2,5-di-(tert-butyl)-3-ethoxycarbonyl-4-formyloxypyrrole

Base Information

• Chemical Name: 1-benzyloxy-2,5-di-(tert-butyl)-3-ethoxycarbonyl-4-formyloxypyrrole
• CAS No.: 1609120-57-1
• Molecular Formula: C₂₃H₃₁NO₅
• Molecular Weight: 401.503
• Mol file: 1609120-57-1.mol

Synonyms:1-benzyloxy-2,5-di-(tert-butyl)-3-ethoxycarbonyl-4-formyloxypyrrole

Chemical Property of 1-benzyloxy-2,5-di-(tert-butyl)-3-ethoxycarbonyl-4-formyloxypyrrole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyloxy-2,5-di-(tert-butyl)-3-ethoxycarbonyl-4-formyloxypyrrole

There total 4 articles about 1-benzyloxy-2,5-di-(tert-butyl)-3-ethoxycarbonyl-4-formyloxypyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1-benzyloxy-2,5-di(tert-butyl)-3-ethoxycarbonyl-4-formylpyrrole (1609120-56-0) → 1-benzyloxy-2,5-di-(tert-butyl)-3-ethoxycarbonyl-4-formyloxypyrrole (1609120-57-1)

Guidance literature:

With Oxone; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1016/j.tetlet.2014.04.004

Reference yield:

1-benzyloxy-2,5-di(tert-butyl)-3-ethoxycarbonylpyrrole (1609120-55-9) → 1-benzyloxy-2,5-di-(tert-butyl)-3-ethoxycarbonyl-4-formyloxypyrrole (1609120-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trichlorophosphate / neat (no solvent) / 0.25 h / Cooling with ice

1.2: 255 / 3 h / 20 - 50 °C

1.3: 50 °C

2.1: Oxone / N,N-dimethyl-formamide / 16 h / 20 °C

With Oxone; trichlorophosphate; In N,N-dimethyl-formamide; 2.1: |Baeyer-Villiger Ketone Oxidation;

DOI:10.1016/j.tetlet.2014.04.004

Reference yield:

benzyl bromide (100-39-0) → 1-benzyloxy-2,5-di-(tert-butyl)-3-ethoxycarbonyl-4-formyloxypyrrole (1609120-57-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C

2.1: trichlorophosphate / neat (no solvent) / 0.25 h / Cooling with ice

2.2: 255 / 3 h / 20 - 50 °C

2.3: 50 °C

3.1: Oxone / N,N-dimethyl-formamide / 16 h / 20 °C

With Oxone; potassium carbonate; trichlorophosphate; In dimethyl sulfoxide; N,N-dimethyl-formamide; 3.1: |Baeyer-Villiger Ketone Oxidation;

DOI:10.1016/j.tetlet.2014.04.004

upstream raw materials:

benzyl bromide

1-hydroxy-2,5-di(tert-butyl)-3-ethoxycarbonylpyrrole

1-benzyloxy-2,5-di(tert-butyl)-3-ethoxycarbonylpyrrole

1-benzyloxy-2,5-di(tert-butyl)-3-ethoxycarbonyl-4-formylpyrrole

Downstream raw materials:

1-benzyloxy-2,5-di-(tert-butyl)-3-ethoxycarbonyl-4-hydroxypyrrole