C₃₉H₄₆FNO₇

Base Information

• Chemical Name: C₃₉H₄₆FNO₇
• CAS No.: 1443773-61-2
• Molecular Formula: C₃₉H₄₆FNO₇
• Molecular Weight: 659.795
• Mol file: 1443773-61-2.mol

Synonyms:C₃₉H₄₆FNO₇

Chemical Property of C₃₉H₄₆FNO₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₉H₄₆FNO₇

There total 5 articles about C₃₉H₄₆FNO₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

C31H31FO7 (1443753-02-3) + (R)-1-((S)-2-chloro-1-methyl-ethyl)-3-methyl-pyrrolidine hydrochloride (1453200-72-0) → C39H46FNO7 (1443773-61-2)

Guidance literature:

C₃₁H₃₁FO₇; With caesium carbonate; In acetone; at 0 ℃; for 0.166667h;

(R)-1-((S)-2-chloro-1-methyl-ethyl)-3-methyl-pyrrolidine hydrochloride; In acetone; at 60 ℃; for 19h;

Reference yield:

3,5-dimethoxyfluorobenzene (52189-63-6) → C39H46FNO7 (1443773-61-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: boron tribromide / dichloromethane / -30 - 25 °C

2.1: boron trifluoride diethyl etherate / 0.25 h / Reflux

3.1: hydrogenchloride / 0.75 h / -10 - 0 °C

4.1: piperidine / benzene / 16 h / Dean-Stark; Reflux

5.1: caesium carbonate / acetone / 0.17 h / 0 °C

5.2: 19 h / 60 °C

With piperidine; hydrogenchloride; boron trifluoride diethyl etherate; boron tribromide; caesium carbonate; In dichloromethane; acetone; benzene;

Reference yield:

5-fluororesorcinol (75996-29-1) → C39H46FNO7 (1443773-61-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: boron trifluoride diethyl etherate / 0.25 h / Reflux

2.1: hydrogenchloride / 0.75 h / -10 - 0 °C

3.1: piperidine / benzene / 16 h / Dean-Stark; Reflux

4.1: caesium carbonate / acetone / 0.17 h / 0 °C

4.2: 19 h / 60 °C

With piperidine; hydrogenchloride; boron trifluoride diethyl etherate; caesium carbonate; In acetone; benzene;

upstream raw materials:

3,5-dimethoxyfluorobenzene

5-fluororesorcinol

1-(2-fluoro-4,6-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethanone

1-(2-fluoro-6-hydroxy-4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethanone

Downstream raw materials:

5-fluoro-3-(4-hydroxyphenyl)-4-methyl-2-{4-[(2S)-2-[(3R)-3-methylpyrrolidin-1-yl]propoxy]phenyl}-2H-chromen-7-ol

C₄₀H₅₀FNO₇