1-(2-fluoro-4,6-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethanone

Base Information

• Chemical Name: 1-(2-fluoro-4,6-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethanone
• CAS No.: 1443753-00-1
• Molecular Formula: C₁₄H₁₁FO₄
• Molecular Weight: 262.237
• Mol file: 1443753-00-1.mol

Synonyms:1-(2-fluoro-4,6-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethanone

Chemical Property of 1-(2-fluoro-4,6-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-fluoro-4,6-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethanone

There total 5 articles about 1-(2-fluoro-4,6-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

4-hydroxyphenylacetate (156-38-7) + 5-fluororesorcinol (75996-29-1) → 1-(2-fluoro-4,6-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethanone (1443753-00-1)

Guidance literature:

With boron trifluoride diethyl etherate; for 0.25h; Reflux;

Reference yield:

3,5-dimethoxyfluorobenzene (52189-63-6) → 1-(2-fluoro-4,6-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethanone (1443753-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / -30 - 25 °C

2: boron trifluoride diethyl etherate / 0.25 h / Reflux

With boron trifluoride diethyl etherate; boron tribromide; In dichloromethane;

Reference yield:

methyl 3-(2-fluoro-4,6-dimethoxyphenyl)-2-(4-methoxyphenyl)-3-oxopropanoate → 1-(2-fluoro-4,6-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethanone (1443753-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 5 h / 150 °C

2: pyridine hydrochloride / 3 h / 180 °C / Inert atmosphere

With pyridine hydrochloride; In dimethyl sulfoxide;

upstream raw materials:

4-hydroxyphenylacetate

5-fluororesorcinol

3,5-dimethoxyfluorobenzene

2-fluoro-4,6-dimethoxybenzoic acid

Downstream raw materials:

1-(2-fluoro-6-hydroxy-4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethanone

C₃₁H₃₁FO₇

C₃₉H₄₆FNO₇

C₄₀H₅₀FNO₇