1,5-dihydro-4-hydroxy-5,5-dimethyl-3-phenyl-2H-pyrrol-2-one

Base Information

• Chemical Name: 1,5-dihydro-4-hydroxy-5,5-dimethyl-3-phenyl-2H-pyrrol-2-one
• CAS No.: 1389334-42-2
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.241
• Mol file: 1389334-42-2.mol

Synonyms:1,5-dihydro-4-hydroxy-5,5-dimethyl-3-phenyl-2H-pyrrol-2-one

Chemical Property of 1,5-dihydro-4-hydroxy-5,5-dimethyl-3-phenyl-2H-pyrrol-2-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1,5-dihydro-4-hydroxy-5,5-dimethyl-3-phenyl-2H-pyrrol-2-one

There total 4 articles about 1,5-dihydro-4-hydroxy-5,5-dimethyl-3-phenyl-2H-pyrrol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

carbon dioxide (124-38-9,18923-20-1) + 2-methyl-4-phenylbut-3-yn-2-amine (143767-97-9) → 1,5-dihydro-4-hydroxy-5,5-dimethyl-3-phenyl-2H-pyrrol-2-one (1389334-42-2)

Guidance literature:

With silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 60 ℃; for 2h; under 750.075 Torr;

DOI:10.1021/ol500806u

Reference yield: 35.0%

→ 1,5-dihydro-4-hydroxy-5,5-dimethyl-3-phenyl-2H-pyrrol-2-one (1389334-42-2) + 2,2-dimethyl-5-oxo-4-phenyl-2,5-dihydro-1H-pyrrol-3-yl acetate (1389334-48-8)

Guidance literature:

Reference yield:

5,5-dimethyltetramic acid (2483-56-9,89464-41-5) + bromobenzene (108-86-1,52753-63-6) → 1,5-dihydro-4-hydroxy-5,5-dimethyl-3-phenyl-2H-pyrrol-2-one (1389334-42-2)

Guidance literature:

5,5-dimethyltetramic acid; bromobenzene; With potassium phosphate; di-tert-butyl (2'-methyl-[1,1'-biphenyl]-2-yl)phosphine; palladium diacetate; In 1,4-dioxane; for 16h; Inert atmosphere; Reflux;

With hydrogenchloride; In water;

upstream raw materials:

5,5-dimethyltetramic acid

bromobenzene

carbon dioxide

2-methyl-4-phenylbut-3-yn-2-amine