5-Methoxypyridine-2-carboxylic acid

Base Information

• Chemical Name: 5-Methoxypyridine-2-carboxylic acid
• CAS No.: 29082-92-6
• Molecular Formula: C7H7NO3
• Molecular Weight: 153.137
• Hs Code.: 2933399090
• European Community (EC) Number: 875-609-5
• DSSTox Substance ID: DTXSID40474746
• Nikkaji Number: J100.092F
• Wikidata: Q72485786
• Mol file: 29082-92-6.mol

Synonyms:29082-92-6;5-METHOXYPYRIDINE-2-CARBOXYLIC ACID;5-Methoxypicolinic acid;5-methoxy-2-pyridinecarboxylic acid;5-Methoxy Picolinic Acid;2-PYRIDINECARBOXYLIC ACID, 5-METHOXY-;MFCD06800961;2-Pyridinecarboxylic acid,5-methoxy-;5-methoxy-picolinic acid;Picolinic acid, 5-methoxy-;AE-562/43286910;SCHEMBL287134;DTXSID40474746;YPKUGKJFOOZLHN-UHFFFAOYSA-N;5-methoxy-2-pyridinecarboxylicacid;5-methoxy-2-pyridylcarboxylic acid;5-Methoxy picolinic acid, AldrichCPR;5-Methoxy-pyridine-2-carboxylic acid;AKOS005199439;CS-W004666;PB17398;AC-24952;DS-10983;SY013190;A5461;FT-0647047;EN300-85193;J-017383;J-517712;F8889-4918;5-methoxypicolinic acid;5-Methoxypyridine-2-carboxylic Acid

Chemical Property of 5-Methoxypyridine-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 172-174 °C
• Refractive Index: 1.55
• Boiling Point: 312.883 °C at 760 mmHg
• PKA: 1.07±0.50(Predicted)
• Flash Point: 143.027 °C
• PSA: 59.42000
• Density: 1.285 g/cm³
• LogP: 0.78840
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 153.042593085
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

97% ^*data from raw suppliers

5-MethoxyPicolinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CN=C(C=C1)C(=O)O
• Uses: A natural imino acid.

Technology Process of 5-Methoxypyridine-2-carboxylic acid

There total 11 articles about 5-Methoxypyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

5-hydroxypicolinic acid (15069-92-8) + methyl iodide (74-88-4) → 5-methoxypyridine-2-carboxylic acid (29082-92-6)

Guidance literature:

With silver(l) oxide; In dimethyl sulfoxide; for 2h; Ambient temperature;

Reference yield:

5-methoxy-2-picoline (55270-47-8) → 5-methoxypyridine-2-carboxylic acid (29082-92-6)

Guidance literature:

With potassium permanganate; In water; toluene;

Reference yield:

5-methoxypyridine-2-carboxylic acid methyl ester (29681-39-8) → 5-methoxypyridine-2-carboxylic acid (29082-92-6)

Guidance literature:

With lithium hydroxide monohydrate; water; In methanol; at 10 - 35 ℃; for 12h;

upstream raw materials:

5-hydroxypicolinic acid

methyl iodide

5-amino-pyridine-2-carboxylic acid

5-nitro-pyridin-2-ylamine

Downstream raw materials:

N-[(2,6-Dichlorophenyl)sulfonyl]-5-methoxy-2-pyridinecarboxamide

5-methoxypyridine-2-carboxylic acid chloride

C₁₅H₁₃NO₄

((2S,4R)-4-hydroxy-2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)(5-methoxypyridin-2-yl)methanone