methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-bromobenzoate

Base Information

Chemical Name:methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-bromobenzoate
CAS No.:1383786-61-5
Molecular Formula:C₁₉H₁₈BrNO₆
Molecular Weight:436.259
Hs Code.:

Synonyms:methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-bromobenzoate

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Chemical Property of methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-bromobenzoate

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Technology Process of methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-bromobenzoate

There total 6 articles about methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-bromobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 622-33-3
N-benzyloxyamine

: 1383786-60-4
methyl 5-bromo-2-(1,3-dimethoxy-1,3-dioxopropan-2-yl)benzoate

: 1383786-61-5
methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-bromobenzoate

Guidance literature:: In toluene; Reflux; Dean-Stark;
DOI:10.1021/jm500109z

Reference yield: 35.0%

: 1383786-61-5
methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-bromobenzoate

Guidance literature:

Reference yield:

: 7304-32-7
2-fluoro-5-nitrobenzoic acid

: 1383786-61-5
methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-bromobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 24 h / 0 °C / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2.2: 15 h / Inert atmosphere; Reflux

3.1: 5%-palladium/activated carbon; hydrogen / methanol / 12 h / 20 °C

4.1: sodium nitrite; hydrogen bromide / 0.17 h / 0 - 5 °C

4.2: 12 h / 0 - 20 °C / Heating

5.1: toluene / Reflux; Dean-Stark

With thionyl chloride; 5%-palladium/activated carbon; hydrogen bromide; hydrogen; sodium hydride; sodium nitrite; In tetrahydrofuran; methanol; toluene; mineral oil;
DOI:10.1021/jm500109z