tert-butyl(2-((4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)ethoxy)diphenylsilanediol

Base Information

Chemical Name:tert-butyl(2-((4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)ethoxy)diphenylsilanediol
CAS No.:955030-51-0
Molecular Formula:C₃₀H₃₈O₄Si
Molecular Weight:490.715
Hs Code.:

Synonyms:tert-butyl(2-((4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)ethoxy)diphenylsilanediol

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Chemical Property of tert-butyl(2-((4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)ethoxy)diphenylsilanediol

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Technology Process of tert-butyl(2-((4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)ethoxy)diphenylsilanediol

There total 4 articles about tert-butyl(2-((4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)ethoxy)diphenylsilanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 955030-34-9
(2R,3R)-5-((tert-butyldiphenylsilyl)oxy)-2-methylpentane-1,3-diol

: 955030-51-0
tert-butyl(2-((4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)ethoxy)diphenylsilanediol

Guidance literature:: With camphor-10-sulfonic acid; In dichloromethane;
DOI:10.1016/j.tetlet.2007.07.156

Reference yield:

: 112897-03-7
3-(tert-butyldiphenylsilyloxy)-1-propanal

: 955030-51-0
tert-butyl(2-((4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)ethoxy)diphenylsilanediol

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / TiCl₄; (-)-Sparteine / CH₂Cl₂ / 0 °C

2: 94 percent / NaBH₄ / tetrahydrofuran; H₂O

3: 92 percent / CSA / CH₂Cl₂

With sodium tetrahydroborate; camphor-10-sulfonic acid; titanium tetrachloride; (-)-sparteine; In tetrahydrofuran; dichloromethane; water; 1: Crimmins asymmetric aldol reaction;
DOI:10.1016/j.tetlet.2007.07.156

Reference yield:

: 1415934-52-9
(2S,3R)-1-((S)-4-benzyl-2-thioxothiazolidin-3-yl)-5-(tert-butyldiphenylsilyloxy)-3-hydroxy-2-methylpentan-1-one

: 955030-51-0
tert-butyl(2-((4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)ethoxy)diphenylsilanediol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 3 h / 20 °C / Inert atmosphere

2: 10-camphorsufonic acid / dichloromethane / 12 h / 20 °C

With sodium tetrahydroborate; 10-camphorsufonic acid; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol3030692