(2R,3R)-5-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-2-methylpentan-1-ol

Base Information

Chemical Name:(2R,3R)-5-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-2-methylpentan-1-ol
CAS No.:955030-35-0
Molecular Formula:C₃₀H₄₀O₄Si
Molecular Weight:492.731
Hs Code.:

Synonyms:(2R,3R)-5-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-2-methylpentan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-5-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-2-methylpentan-1-ol

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Technology Process of (2R,3R)-5-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-2-methylpentan-1-ol

There total 4 articles about (2R,3R)-5-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-2-methylpentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 955030-51-0
tert-butyl(2-((4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)ethoxy)diphenylsilanediol

: 955030-35-0
(2R,3R)-5-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-2-methylpentan-1-ol

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol3030692

Reference yield:

: 955030-34-9
(2R,3R)-5-((tert-butyldiphenylsilyl)oxy)-2-methylpentane-1,3-diol

: 955030-35-0
(2R,3R)-5-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-2-methylpentan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / CSA / CH₂Cl₂

2: 95 percent / DIBAL-H / CH₂Cl₂ / 0 °C

With camphor-10-sulfonic acid; diisobutylaluminium hydride; In dichloromethane;
DOI:10.1016/j.tetlet.2007.07.156

Reference yield:

: 1415934-52-9
(2S,3R)-1-((S)-4-benzyl-2-thioxothiazolidin-3-yl)-5-(tert-butyldiphenylsilyloxy)-3-hydroxy-2-methylpentan-1-one

: 955030-35-0
(2R,3R)-5-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-2-methylpentan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 3 h / 20 °C / Inert atmosphere

2: 10-camphorsufonic acid / dichloromethane / 12 h / 20 °C

3: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; 10-camphorsufonic acid; diisobutylaluminium hydride; In tetrahydrofuran; ethanol; hexane; dichloromethane;
DOI:10.1021/ol3030692