1-BOC-3-METHYLAMINOAZETIDINE

Base Information

• Chemical Name: 1-BOC-3-METHYLAMINOAZETIDINE
• CAS No.: 454703-20-9
• Molecular Formula: C9H18 N2 O2
• Molecular Weight: 186.254
• Hs Code.: 2933990090
• Mol file: 454703-20-9.mol

Synonyms:1-tert-Butoxycarbonyl-3-(methylamino)azetidine;tert-Butyl 3-(methylamino)azetidine-1-carboxylate

Chemical Property of 1-BOC-3-METHYLAMINOAZETIDINE

Chemical Property:

• Boiling Point: 249℃
• PKA: 9.23±0.20(Predicted)
• Flash Point: 105℃
• PSA: 41.57000
• Density: 1.04
• LogP: 1.15390
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl3-(methylamino)azetidine-1-carboxylate 97.0% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T,N
• Statements: 25-50
• Safety Statements: 45-61

MSDS Files:

Useful:

• Uses: 1-Boc-3-(methylamino)azetidine is used as pharmaceutical intermediates.

Technology Process of 1-BOC-3-METHYLAMINOAZETIDINE

There total 1 articles about 1-BOC-3-METHYLAMINOAZETIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methylamine (74-89-5) + tert-butyl-3-iodoazetidine-1-carboxylate (254454-54-1) → 3-methylaminoazetidine-1-carboxylic acid tert-butyl ester (454703-20-9)

Guidance literature:

In ethanol; at 100 ℃; for 24h;

Reference yield: 97.0%

3-methylaminoazetidine-1-carboxylic acid tert-butyl ester (454703-20-9) + C26H25ClF4N4O3Si → C35H41ClF4N6O4Si

Guidance literature:

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 86.0%

3-methylaminoazetidine-1-carboxylic acid tert-butyl ester (454703-20-9) + bis(trichloromethyl) carbonate (32315-10-9) + (R)-5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)-N-(piperidin-3-yl)pyrimidin-2-amine → C33H38ClN7O5S

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

upstream raw materials:

methylamine

tert-butyl-3-iodoazetidine-1-carboxylate

Downstream raw materials:

tert-butyl 3-[[8-amino-2-(3-fluorophenyl)-1,7-naphthyridine-5-carbonyl]amino]azetidine-1-carboxylate

tert-butyl 3-(benzyl(methyl)amino)azetidine-1-carboxylate

Refernces