(3R)-tert-butyl 3-((6-fluoro-3'-methylbiphenyl-2-yl)(2-(methanesulfonyloxy)ethoxy)methyl)piperidine-1-carboxylate

Base Information

• Chemical Name: (3R)-tert-butyl 3-((6-fluoro-3'-methylbiphenyl-2-yl)(2-(methanesulfonyloxy)ethoxy)methyl)piperidine-1-carboxylate
• CAS No.: 952593-35-0
• Molecular Formula: C₂₇H₃₆FNO₆S
• Molecular Weight: 521.65
• Mol file: 952593-35-0.mol

Synonyms:(3R)-tert-butyl 3-((6-fluoro-3'-methylbiphenyl-2-yl)(2-(methanesulfonyloxy)ethoxy)methyl)piperidine-1-carboxylate

Chemical Property of (3R)-tert-butyl 3-((6-fluoro-3'-methylbiphenyl-2-yl)(2-(methanesulfonyloxy)ethoxy)methyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R)-tert-butyl 3-((6-fluoro-3'-methylbiphenyl-2-yl)(2-(methanesulfonyloxy)ethoxy)methyl)piperidine-1-carboxylate

There total 6 articles about (3R)-tert-butyl 3-((6-fluoro-3'-methylbiphenyl-2-yl)(2-(methanesulfonyloxy)ethoxy)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(3R)-tert-butyl 3-((6-fluoro-3'-methylbiphenyl-2-yl)(2-hydroxyethoxy)methyl)piperidine-1-carboxylate + methanesulfonyl chloride (124-63-0) → (3R)-tert-butyl 3-((6-fluoro-3'-methylbiphenyl-2-yl)(2-(methanesulfonyloxy)ethoxy)methyl)piperidine-1-carboxylate (952593-35-0)

Guidance literature:

With triethylamine; In dichloromethane; at -5 - 20 ℃;

Reference yield:

(3R)-tert-butyl 3-((2-ethoxy-2-oxoethoxy)(6-fluoro-3'-methylbiphenyl-2-yl)methyl)piperidine-1-carboxylate (952593-33-8) → (3R)-tert-butyl 3-((6-fluoro-3'-methylbiphenyl-2-yl)(2-(methanesulfonyloxy)ethoxy)methyl)piperidine-1-carboxylate (952593-35-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 16 h / 20 °C

2: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With sodium tetrahydroborate; triethylamine; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2011.06.043

Reference yield:

(R)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (884510-86-5) → (3R)-tert-butyl 3-((6-fluoro-3'-methylbiphenyl-2-yl)(2-(methanesulfonyloxy)ethoxy)methyl)piperidine-1-carboxylate (952593-35-0)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrahydrofuran / 16 h / -78 - 20 °C

2: sodium tetrahydroborate / methanol / 2 h / 20 °C

3: sodium hydride / tetrahydrofuran / 12 h / 0 °C / Reflux

4: sodium tetrahydroborate / methanol / 16 h / 20 °C

5: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With sodium tetrahydroborate; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.bmcl.2011.06.043

upstream raw materials:

methanesulfonyl chloride

(R)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

(3R)-tert-butyl 3-((2-ethoxy-2-oxoethoxy)(6-fluoro-3'-methylbiphenyl-2-yl)methyl)piperidine-1-carboxylate

(R)-tert-butyl 3-(6-fluoro-3'-methylbiphenylcarbonyl)piperidine-1-carboxylate

Downstream raw materials:

(3R)-tert-butyl 3-((2-azidoethoxy)(6-fluoro-3'-methylbiphenyl-2-yl)methyl)piperidine-1-carboxylate

(3R)-tert-butyl 3-((2-aminoethoxy)(6-fluoro-3'-methylbiphenyl-2-yl)methyl)piperidine-1-carboxylate

C₂₃H₂₉FN₂O₃

(3R)-tert-butyl 3-((R)-(2-acetamidoethoxy)(6-fluoro-3'-methylbiphenyl-2-yl)methyl)piperidine-1-carboxylate