1-(2-bromophenyl)ethyl isobutyrate

Base Information

• Chemical Name: 1-(2-bromophenyl)ethyl isobutyrate
• CAS No.: 1268070-44-5
• Molecular Formula: C₁₂H₁₅BrO₂
• Molecular Weight: 271.154
• Mol file: 1268070-44-5.mol

Synonyms:1-(2-bromophenyl)ethyl isobutyrate

Chemical Property of 1-(2-bromophenyl)ethyl isobutyrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-bromophenyl)ethyl isobutyrate

There total 2 articles about 1-(2-bromophenyl)ethyl isobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-bromophenyl)ethanol (5411-56-3) + 2-Methylpropionic anhydride (97-72-3) → 1-(2-bromophenyl)ethyl isobutyrate (1268070-44-5) + 1-(2-bromophenyl)ethyl isobutyrate + (1S)-1-(2-bromophenyl)ethanol (5411-56-3,76116-20-6,118375-26-1,114446-55-8) + (1R)-1-(2-bromophenyl)ethan-1-ol (5411-56-3,114446-55-8,118375-26-1,76116-20-6)

Guidance literature:

With C₂₈H₂₆N₂O; triethylamine; In tert-Amyl alcohol; at 0 ℃; for 20h; optical yield given as %ee; Inert atmosphere; Resolution of racemate;

DOI:10.1021/ol2001705

Reference yield:

2-bromophenyl methyl ketone (2142-69-0) → 1-(2-bromophenyl)ethyl isobutyrate (1268070-44-5) + 1-(2-bromophenyl)ethyl isobutyrate + (1S)-1-(2-bromophenyl)ethanol (5411-56-3,76116-20-6,118375-26-1,114446-55-8) + (1R)-1-(2-bromophenyl)ethan-1-ol (5411-56-3,114446-55-8,118375-26-1,76116-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C / Inert atmosphere

2: C₂₈H₂₆N₂O; triethylamine / tert-Amyl alcohol / 20 h / 0 °C / Inert atmosphere; Resolution of racemate

With sodium tetrahydroborate; C₂₈H₂₆N₂O; triethylamine; In methanol; tert-Amyl alcohol;

DOI:10.1021/ol2001705

upstream raw materials:

2-bromophenyl methyl ketone

1-(2-bromophenyl)ethanol

2-Methylpropionic anhydride