acetic acid 1-(4-benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl ester

Base Information

• Chemical Name: acetic acid 1-(4-benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl ester
• CAS No.: 916599-36-5
• Molecular Formula: C₃₇H₃₅N₃O₇
• Molecular Weight: 633.701
• Mol file: 916599-36-5.mol

Synonyms:acetic acid 1-(4-benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl ester

Chemical Property of acetic acid 1-(4-benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of acetic acid 1-(4-benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl ester

There total 3 articles about acetic acid 1-(4-benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

acetic anhydride (108-24-7) + (S)-1-(3-(4,4′-dimethoxytrityloxy)-2-hydroxypropyl)-N4-benzoylcytosine (127757-40-8) → acetic acid 1-(4-benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl ester (916599-36-5)

Guidance literature:

With pyridine; for 3h;

DOI:10.1021/ol062232u

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → acetic acid 1-(4-benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl ester (916599-36-5)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 12 h / 20 °C

2: 35 percent / NaH / dimethylformamide / Heating

3: 92 percent / pyridine / 3 h

With pyridine; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol062232u

Reference yield:

(S)-glycidyl 4,4’-dimethoxytrityl ether (834906-31-9) → acetic acid 1-(4-benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl ester (916599-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / NaH / dimethylformamide / Heating

2: 92 percent / pyridine / 3 h

With pyridine; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/ol062232u

upstream raw materials:

acetic anhydride

(S)-1-(3-(4,4′-dimethoxytrityloxy)-2-hydroxypropyl)-N4-benzoylcytosine

4,4'-dimethoxytrityl chloride

(S)-glycidyl 4,4’-dimethoxytrityl ether

Downstream raw materials:

acetic acid 2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-1-hydroxymethyl-ethyl ester