ethyl (4R,5R)-7-benzyloxy-5-methoxy-2,2-dimethyl-3-oxo-4-pivaloyloxyheptanoate

Base Information

Chemical Name:ethyl (4R,5R)-7-benzyloxy-5-methoxy-2,2-dimethyl-3-oxo-4-pivaloyloxyheptanoate
CAS No.:1400585-93-4
Molecular Formula:C₂₄H₃₆O₇
Molecular Weight:436.546
Hs Code.:

Synonyms:ethyl (4R,5R)-7-benzyloxy-5-methoxy-2,2-dimethyl-3-oxo-4-pivaloyloxyheptanoate

Suppliers and Price of ethyl (4R,5R)-7-benzyloxy-5-methoxy-2,2-dimethyl-3-oxo-4-pivaloyloxyheptanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl (4R,5R)-7-benzyloxy-5-methoxy-2,2-dimethyl-3-oxo-4-pivaloyloxyheptanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl (4R,5R)-7-benzyloxy-5-methoxy-2,2-dimethyl-3-oxo-4-pivaloyloxyheptanoate

There total 4 articles about ethyl (4R,5R)-7-benzyloxy-5-methoxy-2,2-dimethyl-3-oxo-4-pivaloyloxyheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1400585-73-0
(S)-N-[(2R,3R)-4-benzyloxy-3-methoxy-2-pivaloyloxypentanoyl]-4-isopropyl-1,3-thiazolidine-2-thione

: 97-62-1
Ethyl isobutyrate

: 1400585-93-4
ethyl (4R,5R)-7-benzyloxy-5-methoxy-2,2-dimethyl-3-oxo-4-pivaloyloxyheptanoate

Guidance literature:: Ethyl isobutyrate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

(S)-N-[(2R,3R)-4-benzyloxy-3-methoxy-2-pivaloyloxypentanoyl]-4-isopropyl-1,3-thiazolidine-2-thione; In tetrahydrofuran; at -78 - -50 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jo301569x

Reference yield:

: O-pivaloylglycolic acid

: 1400585-93-4
ethyl (4R,5R)-7-benzyloxy-5-methoxy-2,2-dimethyl-3-oxo-4-pivaloyloxyheptanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 3.25 h / 0 - 20 °C / Inert atmosphere

2.1: titanium tetrachloride / dichloromethane / 0.08 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 0 °C / Inert atmosphere

2.3: 5.5 h / -78 - -20 °C / Inert atmosphere

3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 4 h / -78 - -50 °C / Inert atmosphere

With dmap; titanium tetrachloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo301569x

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1400585-93-4
ethyl (4R,5R)-7-benzyloxy-5-methoxy-2,2-dimethyl-3-oxo-4-pivaloyloxyheptanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 48 h / 20 °C / Inert atmosphere

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 3.25 h / 0 - 20 °C / Inert atmosphere

3.1: titanium tetrachloride / dichloromethane / 0.08 h / 0 °C / Inert atmosphere

3.2: 0.5 h / 0 °C / Inert atmosphere

3.3: 5.5 h / -78 - -20 °C / Inert atmosphere

4.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: 4 h / -78 - -50 °C / Inert atmosphere

With dmap; titanium tetrachloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo301569x