N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(prop-2-en-1-yl)cyclopropanesulfonamide

Base Information

Chemical Name:N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(prop-2-en-1-yl)cyclopropanesulfonamide
CAS No.:1295575-05-1
Molecular Formula:C₂₆H₂₆F₂IN₃O₅S₂
Molecular Weight:689.543
Hs Code.:

Synonyms:N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(prop-2-en-1-yl)cyclopropanesulfonamide

Suppliers and Price of N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(prop-2-en-1-yl)cyclopropanesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(prop-2-en-1-yl)cyclopropanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(prop-2-en-1-yl)cyclopropanesulfonamide

There total 7 articles about N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(prop-2-en-1-yl)cyclopropanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1295575-04-0
N-{2-(3-aminophenoxy)-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl}-1-(prop-2-en-1-yl)cyclopropanesulfonamide

: 594-44-5
Ethanesulfonyl chloride

: 1295575-05-1
N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(prop-2-en-1-yl)cyclopropanesulfonamide

Guidance literature:: With pyridine; at 20 ℃; for 18h;

Reference yield:

: 315-14-0
1,3,5-trifluoro-2-nitrobenzene

: 1295575-05-1
N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(prop-2-en-1-yl)cyclopropanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 121 h / -10 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: sodium dithionite / water; tetrahydrofuran / 1 h / 50 °C

4.1: pyridine / 18 h / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

5.2: pH 10

6.1: pyridine / 18 h / 20 °C

With pyridine; sodium dithionite; caesium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1295575-05-1
N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-1-(prop-2-en-1-yl)cyclopropanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 121 h / -10 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: sodium dithionite / water; tetrahydrofuran / 1 h / 50 °C

4.1: pyridine / 18 h / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

5.2: pH 10

6.1: pyridine / 18 h / 20 °C

With pyridine; sodium dithionite; caesium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;