1,3-bis<2-methoxy-3-(1-tetrahydro-(3H)-pyrimidinonyl)-5-methylphenyl>tetrahydro-2(1H)-pyrimidinone

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Chemical Name:1,3-bis<2-methoxy-3-(1-tetrahydro-(3H)-pyrimidinonyl)-5-methylphenyl>tetrahydro-2(1H)-pyrimidinone
CAS No.:83604-32-4
Molecular Formula:C₂₈H₃₆N₆O₅
Molecular Weight:536.631
Hs Code.:

Synonyms:1,3-bis<2-methoxy-3-(1-tetrahydro-(3H)-pyrimidinonyl)-5-methylphenyl>tetrahydro-2(1H)-pyrimidinone

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Chemical Property of 1,3-bis<2-methoxy-3-(1-tetrahydro-(3H)-pyrimidinonyl)-5-methylphenyl>tetrahydro-2(1H)-pyrimidinone

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Technology Process of 1,3-bis<2-methoxy-3-(1-tetrahydro-(3H)-pyrimidinonyl)-5-methylphenyl>tetrahydro-2(1H)-pyrimidinone

There total 6 articles about 1,3-bis<2-methoxy-3-(1-tetrahydro-(3H)-pyrimidinonyl)-5-methylphenyl>tetrahydro-2(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.8%

: C₂₈H₃₈Cl₂N₆O₅

: 83604-32-4
1,3-bis<2-methoxy-3-(1-tetrahydro-(3H)-pyrimidinonyl)-5-methylphenyl>tetrahydro-2(1H)-pyrimidinone

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol; at 32 ℃; for 15h;
DOI:10.1021/ja00329a059

Reference yield:

: 29455-11-6
2,6-dinitro-4-methylanisole

: 83604-32-4
1,3-bis<2-methoxy-3-(1-tetrahydro-(3H)-pyrimidinonyl)-5-methylphenyl>tetrahydro-2(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 6 steps

1: 55 percent / ammonium sulfide 22percent / methanol / 0.67 h / Heating

2: 90 percent / pyridine / tetrahydrofuran / 30 h / Heating

3: 70 percent / NaOH, benzyltriethylammonium bromide / benzene; H₂O / 96 h / 46 °C

4: 97.6 percent / iron powder, hydrochloric acid / ethanol; H₂O / 3 h / Heating

5: CH₂Cl₂ / 48.5 h / slight initial warming

6: 61.8 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 15 h / 32 °C

With pyridine; hydrogenchloride; sodium hydroxide; ammonium sulfide; potassium tert-butylate; benzyltriethylammonium bromide; iron; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; tert-butyl alcohol; benzene;
DOI:10.1021/ja00329a059

Reference yield:

: 83604-27-7
2-methoxy-3-nitro-5-methylaniline

: 83604-32-4
1,3-bis<2-methoxy-3-(1-tetrahydro-(3H)-pyrimidinonyl)-5-methylphenyl>tetrahydro-2(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / pyridine / tetrahydrofuran / 30 h / Heating

2: 70 percent / NaOH, benzyltriethylammonium bromide / benzene; H₂O / 96 h / 46 °C

3: 97.6 percent / iron powder, hydrochloric acid / ethanol; H₂O / 3 h / Heating

4: CH₂Cl₂ / 48.5 h / slight initial warming

5: 61.8 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 15 h / 32 °C

With pyridine; hydrogenchloride; sodium hydroxide; potassium tert-butylate; benzyltriethylammonium bromide; iron; In tetrahydrofuran; ethanol; dichloromethane; water; tert-butyl alcohol; benzene;
DOI:10.1021/ja00329a059