t-butyl 3-amino-4-[N-(t-butoxycarbonyl)-N-(2-phenylethyl)aminomethyl]benzoate

Base Information

• Chemical Name: t-butyl 3-amino-4-[N-(t-butoxycarbonyl)-N-(2-phenylethyl)aminomethyl]benzoate
• CAS No.: 147290-84-4
• Molecular Formula: C₂₅H₃₄N₂O₄
• Molecular Weight: 426.556

Synonyms:t-butyl 3-amino-4-[N-(t-butoxycarbonyl)-N-(2-phenylethyl)aminomethyl]benzoate

Chemical Property of t-butyl 3-amino-4-[N-(t-butoxycarbonyl)-N-(2-phenylethyl)aminomethyl]benzoate

Chemical Property:

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Technology Process of t-butyl 3-amino-4-[N-(t-butoxycarbonyl)-N-(2-phenylethyl)aminomethyl]benzoate

There total 8 articles about t-butyl 3-amino-4-[N-(t-butoxycarbonyl)-N-(2-phenylethyl)aminomethyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

→ t-butyl (E/Z)-3-[2-(1,4-dimethoxy-1,4-dioxo-2-butenyl)amino]-4-[N-(t-butoxycarbonyl)-N-(2-phenylethyl)aminomethyl]benzoate + t-butyl 3-amino-4-[N-(t-butoxycarbonyl)-N-(2-phenylethyl)aminomethyl]benzoate (147290-84-4)

Guidance literature:

Reference yield: 80.0%

4-[(tert-Butoxycarbonyl-phenethyl-amino)-methyl]-3-nitro-benzoic acid tert-butyl ester (147290-83-3) → t-butyl 3-amino-4-[N-(t-butoxycarbonyl)-N-(2-phenylethyl)aminomethyl]benzoate (147290-84-4)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1021/ja00072a058

Reference yield: 70.0%

→ t-butyl (R,S)-3-[2-(1-methoxy-1-oxo-2-propyl)-amino]-4-[N-(t-butoxycarbonyl]-N-(2-phenylethyl)-aminomethyl]benzoate + t-butyl 3-amino-4-[N-(t-butoxycarbonyl)-N-(2-phenylethyl)aminomethyl]benzoate (147290-84-4)

Guidance literature:

upstream raw materials:

4-[(tert-Butoxycarbonyl-phenethyl-amino)-methyl]-3-nitro-benzoic acid tert-butyl ester

di-tert-butyl dicarbonate

2-nitro-4-(tert-butoxycarbonyl)benzyl bromide

phenethylamine

Downstream raw materials:

methyl (R,S)-8-carboxy-2,3,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-1H-1,4-benzodiazepine-2-acetate

methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate

2-[5-Carboxy-2-(phenethylamino-methyl)-phenylamino]-succinic acid dimethyl ester

methyl (R,S)-8-[[[4-(aminoiminomethyl)phenyl]amino]-carbonyl]-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate

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