2-Propynoic acid, 3-phenyl-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 2-Propynoic acid, 3-phenyl-, 1,1-dimethylethyl ester
• CAS No.: 93139-50-5
• Molecular Formula: C13H14O2
• Molecular Weight: 202.253
• Mol file: 93139-50-5.mol

Synonyms:

Chemical Property of 2-Propynoic acid, 3-phenyl-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propynoic acid, 3-phenyl-, 1,1-dimethylethyl ester

There total 10 articles about 2-Propynoic acid, 3-phenyl-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

phenylpropyolic acid (637-44-5) + isobutene (115-11-7,15220-85-6) → 3-phenylpropionic acid tert-butyl ester (93139-50-5)

Guidance literature:

With sulfuric acid; In ethanol; for 24h; Ambient temperature;

DOI:10.1021/ja00175a039

Reference yield: 92.0%

2-tert-butoxypyridine (83766-88-5) + phenylpropyolic acid (637-44-5) → 3-phenylpropionic acid tert-butyl ester (93139-50-5)

Guidance literature:

With boron trifluoride diethyl etherate; In toluene; at 20 ℃; for 0.5h;

DOI:10.1016/j.tet.2018.05.050

Reference yield: 81.0%

carbon monoxide (201230-82-2) + phenylacetylene (536-74-3) + tert-butyl alcohol (75-65-0) → 3-phenylpropionic acid tert-butyl ester (93139-50-5)

Guidance literature:

With bis(benzonitrile)palladium(II) chloride; silver trifluoromethanesulfonate; N-{(1E,2E)-2-[(2,6-diisopropylphenyl)imino]acenaphthenylidene}-2,6-diisopropylaniline; p-benzoquinone; In tetrahydrofuran; at 20 ℃; for 42h; under 3000.3 Torr; Autoclave; Schlenk technique; Inert atmosphere;

DOI:10.1002/adsc.201600521

upstream raw materials:

phenylpropyolic acid

isobutene

diazo(trimethylsilyl)methyl magnesium bromide

tert-butyl phenylglyoxylate

Downstream raw materials:

tert-butyl (2Z)-2-((dimethyl(phenyl)silyl)(phenyl)methylene)pent-4-enoate

tert-butyl (2E)-2-((dimethyl(phenyl)silyl)(phenyl)methylene)pent-4-enoate

2-methyl-2,6-diphenyl-4H-1,3-dioxin-4-one

6-phenyl-2,2-dimethyl-1,3-dioxin-4-one