1-benzyl-3-(1-cyanocycloprop-1-ylmethyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

Base Information

• Chemical Name: 1-benzyl-3-(1-cyanocycloprop-1-ylmethyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
• CAS No.: 186387-77-9
• Molecular Formula: C₁₇H₁₇N₃O₂
• Molecular Weight: 295.341
• Mol file: 186387-77-9.mol

Synonyms:1-benzyl-3-(1-cyanocycloprop-1-ylmethyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

Chemical Property of 1-benzyl-3-(1-cyanocycloprop-1-ylmethyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-3-(1-cyanocycloprop-1-ylmethyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

There total 3 articles about 1-benzyl-3-(1-cyanocycloprop-1-ylmethyl)-5-methyl-2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-benzyl-5-methyl-2,4(1H,3H)-pyrimidinedione (6306-73-6) + (1-cyanocyclopropylmethyl) methanesulfonate (186387-76-8) → 1-benzyl-3-(1-cyanocycloprop-1-ylmethyl)-5-methyl-2,4(1H,3H)-pyrimidinedione (186387-77-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 50 ℃;

DOI:10.1016/S0960-894X(03)00305-6

Reference yield:

benzyl bromide (100-39-0) → 1-benzyl-3-(1-cyanocycloprop-1-ylmethyl)-5-methyl-2,4(1H,3H)-pyrimidinedione (186387-77-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / K₂CO₃ / dimethylformamide / 25 °C

2: 70 percent / NaH / dimethylformamide / 50 °C

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(03)00305-6

Reference yield:

1-hydroxymethyl-cyclopropanecarbonitrile (98730-77-9) → 1-benzyl-3-(1-cyanocycloprop-1-ylmethyl)-5-methyl-2,4(1H,3H)-pyrimidinedione (186387-77-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / Et₃N / CH₂Cl₂ / 0 °C

2: 70 percent / NaH / dimethylformamide / 50 °C

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(03)00305-6

upstream raw materials:

1-benzyl-5-methyl-2,4(1H,3H)-pyrimidinedione

(1-cyanocyclopropylmethyl) methanesulfonate

benzyl bromide

1-hydroxymethyl-cyclopropanecarbonitrile

Downstream raw materials:

1-(1-benzyl-5-methyl-2,4-dioxo-(1H,3H)-pyrimidin-3-ylmethyl)cycloprop-1-ylmethanol

1-(1-benzyl-5-methyl-2,4-dioxo-(1H,3H)-pyrimidin-3-ylmethyl)-1-cyclopropanecarboxylic acid

1-(1-benzyl-5-methyl-2,4-dioxo-(1H,3H)-pyrimidin-3-ylmethyl)cycloprop-1-ylmethyl methanesulfonate

1-benzyl-5-methyl-3-(1-{4-[2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-ylmethyl}-cyclopropylmethyl)-1H-pyrimidine-2,4-dione