1-(1-benzyl-5-methyl-2,4-dioxo-(1H,3H)-pyrimidin-3-ylmethyl)-1-cyclopropanecarboxylic acid

Base Information

Chemical Name:1-(1-benzyl-5-methyl-2,4-dioxo-(1H,3H)-pyrimidin-3-ylmethyl)-1-cyclopropanecarboxylic acid
CAS No.:186387-78-0
Molecular Formula:C₁₇H₁₈N₂O₄
Molecular Weight:314.341
Hs Code.:

Synonyms:1-(1-benzyl-5-methyl-2,4-dioxo-(1H,3H)-pyrimidin-3-ylmethyl)-1-cyclopropanecarboxylic acid

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Chemical Property of 1-(1-benzyl-5-methyl-2,4-dioxo-(1H,3H)-pyrimidin-3-ylmethyl)-1-cyclopropanecarboxylic acid

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Technology Process of 1-(1-benzyl-5-methyl-2,4-dioxo-(1H,3H)-pyrimidin-3-ylmethyl)-1-cyclopropanecarboxylic acid

There total 6 articles about 1-(1-benzyl-5-methyl-2,4-dioxo-(1H,3H)-pyrimidin-3-ylmethyl)-1-cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 186387-77-9
1-benzyl-3-(1-cyanocycloprop-1-ylmethyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

: 186387-78-0
1-(1-benzyl-5-methyl-2,4-dioxo-(1H,3H)-pyrimidin-3-ylmethyl)-1-cyclopropanecarboxylic acid

Guidance literature:: With hydrogenchloride; In acetic acid; Heating;
DOI:10.1016/S0960-894X(03)00305-6

Reference yield:

: 6306-73-6
1-benzyl-5-methyl-2,4(1H,3H)-pyrimidinedione

: 186387-78-0
1-(1-benzyl-5-methyl-2,4-dioxo-(1H,3H)-pyrimidin-3-ylmethyl)-1-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / NaH / dimethylformamide / 50 °C

2: 90 percent / concd HCl / acetic acid / Heating

With hydrogenchloride; sodium hydride; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00305-6

Reference yield:

: 100-39-0
benzyl bromide

: 186387-78-0
1-(1-benzyl-5-methyl-2,4-dioxo-(1H,3H)-pyrimidin-3-ylmethyl)-1-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / K₂CO₃ / dimethylformamide / 25 °C

2: 70 percent / NaH / dimethylformamide / 50 °C

3: 90 percent / concd HCl / acetic acid / Heating

With hydrogenchloride; sodium hydride; potassium carbonate; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00305-6