(S)-2-AMINO-3-(4-METHOXY-PHENYL)-2-METHYL-PROPIONIC ACID ETHYL ESTER

Base Information

Chemical Name:(S)-2-AMINO-3-(4-METHOXY-PHENYL)-2-METHYL-PROPIONIC ACID ETHYL ESTER
CAS No.:25441-65-0
Molecular Formula:C₁₃H₁₉NO₃
Molecular Weight:237.299
Hs Code.:2922509090
Mol file:25441-65-0.mol

Synonyms:Alanine,3-(p-methoxyphenyl)-2-methyl-, ethyl ester (8CI)

Suppliers and Price of (S)-2-AMINO-3-(4-METHOXY-PHENYL)-2-METHYL-PROPIONIC ACID ETHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of (S)-2-AMINO-3-(4-METHOXY-PHENYL)-2-METHYL-PROPIONIC ACID ETHYL ESTER

Chemical Property:

Boiling Point:334.0±27.0 °C(Predicted)
PKA:7.47±0.25(Predicted)
PSA：61.55000
Density:1.081±0.06 g/cm3(Predicted)
LogP:2.21850

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-2-AMINO-3-(4-METHOXY-PHENYL)-2-METHYL-PROPIONIC ACID ETHYL ESTER

There total 6 articles about (S)-2-AMINO-3-(4-METHOXY-PHENYL)-2-METHYL-PROPIONIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61924-67-2
ethyl 2-nitro-3-(4-methoxyphenyl)propionate

: 25441-65-0
2-amino-3-(4-methoxyphenyl)-2-methylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / aq. tetrabutylammonium hydroxide / CH₂Cl₂ / 48 h / 20 °C

2: 100 percent / H₂ / Pd/C / methanol / 12 h / 20 °C

With tetra(n-butyl)ammonium hydroxide; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jo0709450

Reference yield:

: 55895-90-4
(±)-ethyl 2-amino-3-(4-methoxyphenyl)propanoate

: 25441-65-0
2-amino-3-(4-methoxyphenyl)-2-methylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: F₂; MeCN; H₂O / CH₂Cl₂ / 0 °C

2: 90 percent / aq. tetrabutylammonium hydroxide / CH₂Cl₂ / 48 h / 20 °C

3: 100 percent / H₂ / Pd/C / methanol / 12 h / 20 °C

With tetra(n-butyl)ammonium hydroxide; water; hydrogen; fluorine; acetonitrile; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jo0709450

Reference yield:

: 927196-12-1
acetic acid 3-(4-methoxyphenyl)-2-(4-methoxyphenylazo)-2-methylpropyl ester

: 25441-65-0
2-amino-3-(4-methoxyphenyl)-2-methylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water; zinc / methanol / 20 °C / Reflux

2: sodium periodate; sodium dichromate; sulfuric acid / water / 20 h / 20 °C

3: thionyl chloride / -10 - 20 °C / Reflux

With hydrogenchloride; sodium periodate; thionyl chloride; sodium dichromate; sulfuric acid; water; zinc; In methanol; water;
DOI:10.1016/j.tetlet.2010.11.137