4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butylamine

Base Information

Chemical Name:4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butylamine
CAS No.:75934-20-2
Molecular Formula:C₁₆H₂₄N₂O₂
Molecular Weight:276.379
Hs Code.:

Synonyms:4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butylamine

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Chemical Property of 4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butylamine

Chemical Property:

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Technology Process of 4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butylamine

There total 9 articles about 4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 75934-18-8
2-{4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butyl}-isoindole-1,3-dione

: 75934-20-2
4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butylamine

Guidance literature:: With hydrazine; In ethanol; for 2h; Heating;
DOI:10.1021/jo00317a027

Reference yield:

: 63667-83-4
1-(but-3-en-1-yl)-2-methoxybenzene

: 75934-20-2
4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butylamine

Guidance literature:: Multi-step reaction with 6 steps

1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / 1) in dry ether at reflux for 1h 2) CO₂ as a continous stream for 1h

2: thionyl chloride

3: sodium hydroxide; boron trifluoride-tetrahydrofuran complex; dihydrogen peroxide / 1) for 1h 2) at 50 deg C for 1h

4: triethylamine / dichloromethane / -22 °C

5: N,N-dimethyl-formamide

6: hydrazine / ethanol / 2 h / Heating

With sodium hydroxide; n-butyllithium; thionyl chloride; boron trifluoride-tetrahydrofuran complex; N,N,N,N,-tetramethylethylenediamine; dihydrogen peroxide; triethylamine; hydrazine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00317a027

Reference yield:

: 75934-25-7
3-(3-Butenyl)anisic Acid

: 75934-20-2
4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butylamine

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride

2: sodium hydroxide; boron trifluoride-tetrahydrofuran complex; dihydrogen peroxide / 1) for 1h 2) at 50 deg C for 1h

3: triethylamine / dichloromethane / -22 °C

4: N,N-dimethyl-formamide

5: hydrazine / ethanol / 2 h / Heating

With sodium hydroxide; thionyl chloride; boron trifluoride-tetrahydrofuran complex; dihydrogen peroxide; triethylamine; hydrazine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00317a027