2-{4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butyl}-isoindole-1,3-dione

Base Information

Chemical Name:2-{4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butyl}-isoindole-1,3-dione
CAS No.:75934-18-8
Molecular Formula:C₂₄H₂₆N₂O₄
Molecular Weight:406.481
Hs Code.:

Synonyms:2-{4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butyl}-isoindole-1,3-dione

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Chemical Property of 2-{4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butyl}-isoindole-1,3-dione

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Technology Process of 2-{4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butyl}-isoindole-1,3-dione

There total 8 articles about 2-{4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butyl}-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 75948-76-4
2-[3-(4-Methanesulfonyl-butyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

: 1074-82-4
potassium phtalimide

: 75934-18-8
2-{4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butyl}-isoindole-1,3-dione

Guidance literature:: In N,N-dimethyl-formamide;
DOI:10.1021/jo00317a027

Reference yield: 84.0%

: C₁₇H₂₅NO₅S

: 1074-82-4
potassium phtalimide

: 75934-18-8
2-{4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butyl}-isoindole-1,3-dione

Guidance literature:: In N,N-dimethyl-formamide;
DOI:10.1021/jo00317a027

Reference yield:

: 63667-83-4
1-(but-3-en-1-yl)-2-methoxybenzene

: 75934-18-8
2-{4-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-butyl}-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / 1) in dry ether at reflux for 1h 2) CO₂ as a continous stream for 1h

2: thionyl chloride

3: sodium hydroxide; boron trifluoride-tetrahydrofuran complex; dihydrogen peroxide / 1) for 1h 2) at 50 deg C for 1h

4: triethylamine / dichloromethane / -22 °C

5: N,N-dimethyl-formamide

With sodium hydroxide; n-butyllithium; thionyl chloride; boron trifluoride-tetrahydrofuran complex; N,N,N,N,-tetramethylethylenediamine; dihydrogen peroxide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00317a027