3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Base Information

Chemical Name:3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide
CAS No.:1419221-60-5
Molecular Formula:C₁₉H₁₉BF₄N₂O₃
Molecular Weight:410.176
Hs Code.:

Synonyms:3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Suppliers and Price of 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide 97%
1g
$ 1191.00

Chemenu
3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide 95%
1g
$ 637.00

A1 Biochem Labs
3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide 95%
2.5 g
$ 1100.00

Total 8 raw suppliers

Chemical Property of 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Chemical Property:

Boiling Point:431.8±45.0 °C(Predicted)
Density:1.30±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

There total 4 articles about 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1419221-61-6
4-bromo-3-fluoro-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

: 73183-34-3
bis(pinacol)diborane

: 1419221-60-5
3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Guidance literature:: With potassium acetate; palladium diacetate; XPhos; In 1,4-dioxane; at 90 ℃; for 6h;
DOI:10.1021/acsmedchemlett.5b00463

Reference yield:

: 106447-97-6
2-amino-4-(trifluoromethyl)pyridine

: 153556-42-4
4-bromo-3-fluorobenzoic acid

: 1419221-60-5
3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; HATU / tetrahydrofuran / 60 h / 20 - 60 °C

2: potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 110 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; triethylamine; HATU; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 153556-42-4
4-bromo-3-fluorobenzoic acid

: 1419221-60-5
3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine; dmap / tetrahydrofuran / 12 h / 50 °C

3: XPhos; potassium acetate; palladium diacetate / 1,4-dioxane / 6 h / 90 °C

With dmap; oxalyl dichloride; potassium acetate; palladium diacetate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; XPhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/acsmedchemlett.5b00463