5-chloro-N-((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)-2-methyl-3-((1-methylpiperidin-4-yl)oxy)benzamide

Base Information

Chemical Name:5-chloro-N-((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)-2-methyl-3-((1-methylpiperidin-4-yl)oxy)benzamide
CAS No.:1617501-09-3
Molecular Formula:C₂₂H₂₈ClN₃O₃
Molecular Weight:417.936
Hs Code.:

Synonyms:5-chloro-N-((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)-2-methyl-3-((1-methylpiperidin-4-yl)oxy)benzamide

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Chemical Property of 5-chloro-N-((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)-2-methyl-3-((1-methylpiperidin-4-yl)oxy)benzamide

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Technology Process of 5-chloro-N-((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)-2-methyl-3-((1-methylpiperidin-4-yl)oxy)benzamide

There total 7 articles about 5-chloro-N-((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)-2-methyl-3-((1-methylpiperidin-4-yl)oxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₈ClNO₃

: 1617501-16-2
3-amino-5-(aminomethyl)-2,6-dimethylpyridin-4(1H)-one hydrochloride

: 1617501-09-3
5-chloro-N-((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)-2-methyl-3-((1-methylpiperidin-4-yl)oxy)benzamide

Guidance literature:: With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 7499-06-1
5-chloro-2-methylbenzoic acid

: 1617501-09-3
5-chloro-N-((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)-2-methyl-3-((1-methylpiperidin-4-yl)oxy)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid; 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione / 2 h

2.1: copper(l) iodide; 8-quinolinol; potassium hydroxide / tert-butyl alcohol; dimethyl sulfoxide; water / 24 h / 100 °C / Inert atmosphere

3.1: thionyl chloride / 0.25 h / Cooling with ice

3.2: 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 75 °C

5.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 20 °C

6.1: acetic acid; sodium tris(acetoxy)borohydride / methanol / 18 h / 20 °C

7.1: methanol; sodium hydroxide / 2 h / 20 °C

8.1: 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 3 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; methanol; copper(l) iodide; 8-quinolinol; thionyl chloride; 1-hydroxy-7-aza-benzotriazole; 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione; sulfuric acid; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1549275-48-0
5-chloro-3-iodo-2-methylbenzoic acid

: 1617501-09-3
5-chloro-N-((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)-2-methyl-3-((1-methylpiperidin-4-yl)oxy)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper(l) iodide; 8-quinolinol; potassium hydroxide / tert-butyl alcohol; dimethyl sulfoxide; water / 24 h / 100 °C / Inert atmosphere

2.1: thionyl chloride / 0.25 h / Cooling with ice

2.2: 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 75 °C

4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 20 °C

5.1: acetic acid; sodium tris(acetoxy)borohydride / methanol / 18 h / 20 °C

6.1: methanol; sodium hydroxide / 2 h / 20 °C

7.1: 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 3 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; methanol; copper(l) iodide; 8-quinolinol; thionyl chloride; 1-hydroxy-7-aza-benzotriazole; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;