tert-butyl 4-(5-chloro-3-(methoxycarbonyl)-2-methylphenoxy)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(5-chloro-3-(methoxycarbonyl)-2-methylphenoxy)piperidine-1-carboxylate
CAS No.:1617501-17-3
Molecular Formula:C₁₉H₂₆ClNO₅
Molecular Weight:383.872
Hs Code.:

Synonyms:tert-butyl 4-(5-chloro-3-(methoxycarbonyl)-2-methylphenoxy)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(5-chloro-3-(methoxycarbonyl)-2-methylphenoxy)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(5-chloro-3-(methoxycarbonyl)-2-methylphenoxy)piperidine-1-carboxylate

There total 5 articles about tert-butyl 4-(5-chloro-3-(methoxycarbonyl)-2-methylphenoxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: methyl 5-chloro-3-hydroxy-2-methylbenzoate

: 141699-59-4
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

: 1617501-17-3
tert-butyl 4-(5-chloro-3-(methoxycarbonyl)-2-methylphenoxy)piperidine-1-carboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 18h;

Reference yield: 80.0%

: methyl 5-chloro-3-hydroxy-2-methylbenzoate

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1617501-17-3
tert-butyl 4-(5-chloro-3-(methoxycarbonyl)-2-methylphenoxy)piperidine-1-carboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 55 ℃; for 4h; Inert atmosphere;

Reference yield:

: 7499-06-1
5-chloro-2-methylbenzoic acid

: 1617501-17-3
tert-butyl 4-(5-chloro-3-(methoxycarbonyl)-2-methylphenoxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione / 2 h

2.1: copper(l) iodide; 8-quinolinol; potassium hydroxide / tert-butyl alcohol; dimethyl sulfoxide; water / 24 h / 100 °C / Inert atmosphere

3.1: thionyl chloride / 0.25 h / Cooling with ice

3.2: 20 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 h / 55 °C / Inert atmosphere

With copper(l) iodide; 8-quinolinol; thionyl chloride; 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione; di-isopropyl azodicarboxylate; sulfuric acid; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; water; dimethyl sulfoxide; tert-butyl alcohol;